摘要
茚酮类化合物不仅广泛存在于天然产物中,而且在药物研发、杀虫剂等方面有广阔的应用前景。以3-氯丙酰氯及取代苯(Cl—、Br—、CH_3—及CH_3O—)为原料,通过路易斯酸催化,先后经过付克酰基化、付克烷基化来合成相应的目标化合物(Cl—、Br—、CH_3—及HO—)。优化了这类化合物的合成条件,选择新型的AlCl_3-LiCl熔盐体系作为付克烷基化的路易斯酸催化剂和反应溶剂,大大提高了茚酮类化合物的合成产率,总收率可达到77%～82%。目标化合物的结构通过核磁共振分析确定。
Indanone compounds not only exist widely in natural products,but also have broad application prospects in drug development, insecticides and so on.With 3-chloroacetic chloride and substituted benzene( Cl-,Br-,CH3- and CH3O-) as raw materials, the target compounds( Cl-,Br-,CH3- and HO-) were synthesized via Friedel-Crafts acylation reaction and alkylation reaction in the presence of Lewis acid catalyst.The reaction conditions were optimized using the new type AlCl3-LiCl molten salt as Lewis acid catalyst and reaction solvent for Friedel-Crafts alkylation reaction, the yield of the target compounds were up to 77%~ 82%.The compounds were characterized by 1HNMR and 13CNMR.
作者
潘继刚
张光辉
姚兵
陶勇凯
PAN Ji-gang;ZHANG Guang-hui;YAO Bing;TAO Yong-kai(School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030031,China)
出处
《化学试剂》
CAS
北大核心
2019年第5期526-530,共5页
Chemical Reagents
基金
山西大学大学生创新实验项目(091010823)
大田粮食作物生物配肥集成技术山西省高校协同创新中心资助项目(晋教科[2016]5号)
