摘要
目的:研究胡椒酸乙二胺(PAE)的急性毒性作用及安全性。方法:40只昆明种小鼠随机分成实验组和对照组,各20只,实验组用0.5%羧甲基纤维素钠(CMC-Na)配制的PAE混悬液对小鼠进行灌胃,对照组用0.5%CMC-Na溶液灌胃,采用最大耐受量(MTD)法,给药剂量为5 g/kg,每天1次,连续14 d,观察给药后小鼠有无异常反应及死亡情况,期间记录体重变化,实验结束解剖动物,称量脏器湿重,计算脏器系数。结果:给药后小鼠未出现死亡和毒性反应,解剖肉眼观脏器未见病变,分析比较两组小鼠体重、脏器湿重及脏器系数,差异均无统计学意义(P>0.05)。结论:胡椒酸乙二胺属低毒性化合物。
Objective To study the acute toxicity and safety of the piperic acid ethylenediamine(PAE). Methods 40 Kunming mice were randomly divided into experimental group and control group, with 20 mice in each group. The experimental group was intragastrically administered with PAE suspension formulated with 0.5% Sodium carboxymethyl cellulose(CMC-Na), and the control group was gavaged with 0.5% CMC-Na solution. Use the maximum tolerance method(MTD), the intragastric dose was 5 g/kg, the mice were given by gavage once a day for 14 days, observed any adverse reactions and deaths after the treatment, and the body weight changes were recorded during the experiment. At the end of the experiment dissected the animal, weighed the wet weight of the organ, and calculated the organ coefficient. Results There was no death and toxicity in the mice after administration, and no pathological changes were observed in the naked eye, analysis and comparison of body weight, organ wet weight and organ coefficient of the two groups of mice, the difference was not statistically significant(P>0.05). Conclusion Piperonic acid ethylenediamine is a low toxicity compound.
作者
张瑞
韩加
吕梅霞
吾布力卡司木.艾克拜尔
彭冰鑫
吐尔孙拜克.叶尔达
ZHANG Rui;HAN Jia;LV MeiXia;Wu Bu Li Ka Si Mu·AI KE BAI ER;PENG BingXin;Tu er sun bai ke·YE ER DA(Department of Nutrition and Food Hygiene,College of Public Health, Xinjiang Medical University,Urumqi 830011,China;College of Chemistry and Biological Sciences, Yili Normal University, Yining 835000,China)
出处
《中国民族民间医药》
2019年第7期21-23,共3页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
国家自然科学基金(21462046)
关键词
胡椒酸乙二胺
小鼠
急性毒性
Piperic Acid Ethylenediamine(PAE)
Mice
Acute Toxicity
