摘要
去泛素化酶9X(USP9X)是去泛素化酶(DUBs)中的一员。USP9X是X染色体连锁的泛素特异性蛋白酶(U SPs),可以通过稳定不同的底物,发挥相应的生物学效应。USP9X在信号通路转导、细胞生长及迁移、免疫应答、干细胞的自我更新及分化、神经系统功能以及肿瘤发生发展进程中均起着重要作用。因其在消化道肿瘤发生发展中的重要作用以及作为药物靶点的可行性,本文综述了USP9X在常见的消化系统恶性肿瘤发生发展中作用的研究进展。
Ubiquitin-specific protease 9X (USP9X) is one of the ubiquitin-specific protease(USPs) families of deubiquitinating enzymes (DUBs). USP9X is DUBs of X chromosome chain, which can play corresponding biological effects by stabilizing different substrates. USP9X plays an important role in cell signaling transduction, regulation of cell growth and migration, immune response, self-renewal and differentiation of stem cells, neurological function and carcinogenesis. Because of its important role in the development of digestive tract tumors and its feasibility as a drug target, this paper reviews the research progress of USP9X in the occurrence and development of common malignant tumors of digestive system.
作者
王捷夫
王茜
WANG Jie-fu;WANG Qian(Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory ofCancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China)
出处
《天津医药》
CAS
北大核心
2019年第5期542-548,共7页
Tianjin Medical Journal
基金
国家自然科学基金青年科学基金资助项目(81702794)
