摘要
糖尿病肾病(diabetic nephropathy,DN)是临床常见的糖尿病(diabetes melllitus,DM)并发症,其特征为DM肾小球细胞的硬化坏死。目前,临床约1/2的DM患者并发DN,其结果均为肾脏坏死。DM患者死亡的主要原因是DM的各种并发症,其中肾脏损害最难痊愈。目前DN的发病机制尚未阐述完全,DN与炎性反应机制关系十分密切,在DN发病过程中,肿瘤坏死因子受体(TNF-α),转化生长因子(TGF-β),单核细胞趋化蛋白(MCP-1)、白介素(IL)等参与了细胞黏附、分化与组织损伤。本文就参与DN发病的主要炎性细胞因子作一综述。
Diabetic nephropathy(DN) is a clinical common complication of diabetes melllitus(DM),which is characterized by the hardening and necrosis of diabetic glomerular cells. Currently, about half of diabetic patients are complicated by diabetic nephropathy that results in renal necrosis. The main cause of death in diabetic patients is various complications of diabetes,in which, kidney damage is the most difficult to be cured. At present the pathogenesis of diabetic nephropathy is not completely expounded, diabetic nephropathy is closely correlated with inflammatory reaction mechanism during DN pathogenesis,and tumor necrosis factor receptor(TNF alpha), transforming growth factor(TGF-beta), monocyte chemotactic protein(MCP-1), interleukin(IL) are involved in cell adhesion, differentiation and tissue damage. This article will review the main inflammatory cytokines that are involved in the pathogenesis of DN.
作者
李蕾蕾
朱虹
LI Leilei;ZHU Hong(Clinical Medical College of Yangzhou University,Jiangsu,Yangzhou 225001,China)
出处
《河北医药》
CAS
2019年第9期1413-1417,共5页
Hebei Medical Journal
基金
江苏省中医药局科技项目(编号:YB201841)
关键词
糖尿病肾病
炎症机制
炎性细胞因子
综述
diabetic nephropathy
inflammatory mechanism
inflammatory cytokines
review
