摘要
调节性B细胞是B细胞的一种亚群,主要通过分泌白细胞介素-10,转化生产因子-β等细胞因子发挥负向调节作用而参与免疫耐受,抑制炎性反应。本文主要综述调节性B细胞的表型、分类、相关分子、功能等在系统性红斑狼疮、系统性硬化症、银屑病及天疱疮等自身免疫性皮肤病中的研究进展。并探讨调节性B细胞靶向疗法的前景及意义。
Regulatory B cells is a subgroup of B cells, they mainly secrete interleukin - 10, produce factors, such as transforming growth factor - p and they exert a negative regulatory role in immune tolerance to inhibit the inflammatory response. This paper mainly summarizes the research progress of regulatory B cells' phenotypes, classifications and function of related molecules in autoimmune skin diseases, such as systemic lupus erythematosus, systemic sclerosis, psoriasis and pemphigus. Last but not least, we will discuss the prospect and significance of regulatory B cells targeted therapies.
作者
沈婷婷
高慧
Shen Tingting;Gao Hui(School of Clinical Medicine, Ycmgzhou University, Yangzhou, Zhejiang 225000, China)
出处
《中国基层医药》
CAS
2019年第8期1021-1024,共4页
Chinese Journal of Primary Medicine and Pharmacy
