摘要
目的:通过PET自由呼吸采集方法与常规ANZAI呼吸门控系统采集方法的比较,研究自由呼吸门控技术的价值。方法:采用美国国家电气制造商协会(NEMA)体模,模型为11.49 ml尺寸球体,设定该模型体积和标定浓度为体积标准值和浓度标准值,标定^(18)F-氟代脱氧葡萄糖(18F-FDG)溶液浓度为2.85 MBq/ml,先后用ANZAI呼吸门控系统和自由呼吸方法采集,可得到ANZAI门控系统采集6时相门控重建图像平均测量值(GATED)和非门控重建图像测量值(NON-GATED)、自由呼吸采集方法6时相门控重建图像平均测量值(FREE)和非门控重建图像测量值(NON-FREE),对GATED、FREE、NON-GATED和NON-FREE标准值进行比较分析。结果:ANZAI门控采集方法与自由呼吸采集方法测得体积、平均浓度及最大浓度数据比较中,差异均无统计学意义(P>0.05);两种方法门控触发信号完全一致,均可对患者肺部病灶呼吸运动伪影进行校正。两种门控重建图像测得的模型体积明显小于非门控图像测得的模型体积,GATED为(11.27±0.09)ml,NON-GATED为(15.22±15.08)ml;FREE为(11.32±0.07)ml,NON-FREE为(15.42±0.31)ml;平均浓度测量两种门控重建图像测量值分别为(2.94±0.11)MBq和2.81±0.17)MBq,理论值分别为(2.87±0.05)MBq和(2.75±0.06)MBq,其差值均小于非门控重建图像测量值与理论值差值,ΔGATED/理论值与NON-GATED/理论值分别为(4.36±1.21)%和(51.11±3.01)%、ΔFREE/理论值与ΔNON-FREE/理论值平均值分别约为(5.36±3.00)%和(37.58±2.88)%,两组数据比较差异有统计学意义(t=-27.72,t=-11.86;P<0.05),两种门控采集方法均优于非门控采集方法。结论:自由呼吸采集方法操作简便,结果准确可靠,门控触发信号稳定,适合应用为临床常规呼吸门控采集的方法。
Objective: To research the value of gating techniques with free breathing by comparing the collection methods with free-breathing of PET and routine collection method of ANZAI respiring gating system. Methods: A NEMA model ball with 11.49 ml was adopted, and its model volume and model concentration were standard value of volume and concentration. And the concentration of 18F-FDG solution was calibrated as 2.85 MBq/ml. ANZAI gating system and free breathing method were successively adopted to collect average measurement value of gating reconstruction imaging (GATED) and non-gating reconstruction imaging (NON-GATED) of 6 phase of ANZAI gating system, and average measurement value of gating reconstruction imaging (FREE) and non-gating reconstruction imaging (NON-FREE) of 6 phase of free breathing method. And the standard values of GATED, FREE, NONGATED and NON-FREE were compared and analyzed. Results: The differences of volume, average concentration and maximum concentration between ANZAI gating collection method and free breathing collection method were no significant (P>0.05). The gating trigger signals of two methods were coincidence. And both them could implement verification for respiratory motion artifact of lung lesion of patients. The model volumes of gating reconstruction imaging in two kinds of methods were obviously less than that of non-gating imaging, and GATED was 11.27±0.09 ml, and NON -GATED was 15.22±15.08 ml, and FREE was 11.32±0.07 ml, and NON-FREE was 15.42±0.31 ml. And the average concentration values that measured by two kinds of gating reconstruction imaging were 2.94±0.11 MBq and 2.81±0.17MBq, respectively, and their theoretical value were 2.87±0.05 MBq and 2.75±0.06MBq, and the differences of them were smaller than that of NON-GATED reconstruction imaging. The rates of Δ GATED/theoretical value and the NON-GATED/theoretical value were 4.36±1.21% and 51.11±3.01% respectively. And the rates of Δ FREE/theoretical value and Δ NON-FREE/theoretical value were 5.36±3.00% and 37.58±2.
作者
王瞳
李楠
朱文佳
朱朝晖
张悦
霍力
李方
张辉
WANG Tong;LI Nan;ZHU Wen-jia(Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China)
出处
《中国医学装备》
2019年第5期10-14,共5页
China Medical Equipment
基金
国家重点研发计划(2017YFC0114003)"PET/CT分子影像示范及其支撑技术研究"
关键词
自由呼吸
呼吸门控
平均浓度
最大浓度
PET
Free-breathing
Respiratory gating
Average concentration
The maximum concentration
Positronemission tomography
