摘要
目的探究奥卡西平联合拉莫三嗪治疗癫痫患儿的疗效,以及对神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)水平的影响。方法选取2015年1月—2017年12月郑州大学附属郑州中心医院收治的94例癫痫患儿,随机分为观察组和对照组,对照组口服奥卡西平,观察组在对照组的基础上口服拉莫三嗪,治疗6个月后,对两组患儿临床疗效、不良反应发生率、治疗前后脑电图变化情况进行比较,同时检测NSE、GFAP等指标的水平。结果观察组的治疗总有效率为91.49%,对照组为74.47%,经χ~2检验,差异有统计学意义(P <0.05),观察组不良反应发生率仅为8.51%,对照组为21.28%,经χ~2检验,差异有统计学意义(P<0.05)。观察组患儿治疗后θ频段功率低于对照组(P<0.05)。结论奥卡西平联合拉莫三嗪可有效提高癫痫的治疗效果,减少服药期间不良反应发生率,值得在临床中推广应用。
Objectives To explore the effect of oxcarbazepine combined with lamotrigine on the treatment of epileptic children and the levels of NSE and GFAP. Methods A total of 94 children with epilepsy treated in our hospital from January 2015 to December 2017 were randomly divided into the observation group and the control group. The control group was given oral oxcarbazepine, and the observation group was given lamotrigine on the basis of the control group for 6 months. The clinical efficacy, the incidence of adverse reactions and the changes of electroencephalogram before and after treatment were compared between the two groups, and the levels of NSE and GFAP were detected. Results After the treatment, the total effective rate of the observation group was 91.49%, the control group was 74.47%(χ2=10.260, P =0.001). The incidence of adverse reaction in the observation group was 8.51%, and the control group was 21.28%(χ2=6.431, P =0.011). After treatment, the θ frequency range in the observation group was lower than that in the control group (t =3.759, P =0.000), and there were no different for other frequency range. Conclusions The combination of oxcarbazepine and lamotrigine can effectively improve the therapeutic effect of epilepsy, reduce the incidence of adverse reactions during the medication and it was worthy of clinical application.
作者
曾芳
任晓幸
黎玉环
Fang Zeng;Xiao-xing Ren;Yu-huan Li(Department of Neurology, Zhengzhou Center Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450052, China;Department of Ultrasonography, Zhengzhou Center Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450052, China;Department of Neurology, the Second People’s Hospital of Yichang, Yichang, Hubei 443000, China)
出处
《中国现代医学杂志》
CAS
2019年第10期91-95,共5页
China Journal of Modern Medicine
