摘要
目的探讨CD15抗原、CD44v6蛋白及基质金属蛋白酶-3(MMP-3)在乳腺癌中的表达,并对其进行相关性分析。方法选取2014年7月—2016年7月青海省肿瘤医院收治的80例乳腺癌患者,采用免疫组织化学SP法检测患者乳腺癌组织中及其癌旁组织中CD15抗原、CD44v6蛋白及MMP-3的表达水平,观察其在乳腺癌组织及癌旁组织的表达差异。结果乳腺癌组织中的CD15抗原、CD44v6蛋白及MMP-3总阳性率较癌旁组织高(P<0.05)。乳腺癌组织中CD15抗原、CD44v6蛋白及MMP-3的表达与淋巴结转移情况和组织学分级呈正相关(P<0.05),而与患者的年龄、绝经情况无相关性(P>0.05);CD15抗原、CD44v6蛋白及MMP-3在乳腺癌组织中的表达呈正相关(P<0.05)。结论 CD15抗原、CD44v6蛋白及MMP-3在乳腺癌组织中的表达具有一定的相关性,临床上联合检测CD15抗原、CD44v6蛋白及MMP-3的表达水平,对鉴别诊断乳腺肿瘤良恶性病变程度具有重要参考价值。
Objective To observe the expression of CD15 antigen, CD44v6 protein and matrix metalloproteinase-3 (MMP-3) in breast cancer and analyze their correlation. Methods Totally 80 cases of breast cancer patients from July 2014 to July 2016 admitted to our hospital diagnosis and treatment were selected as the research object, and the expression level and difference of CD15 antigen, CD44v6 protein and MMP-3 were detected by immunohistochemistry in tumor tissues and adjacent tissues. Results The total positive rate of CD15 antigen, CD44v6 protein and MMP-3 in tumor tissues was higher than those in adjacent tissues, and the difference between the two groups was statistically significant (P < 0.05). The expression of CD15 antigen, CD44v6 protein and MMP- 3 in breast cancer tissues were positively correlated with lymph node metastasis and histological grade (P < 0.05), but had no significant correlation with the age and menopause (P > 0.05). The expression of CD15 antigen, CD44v6 protein and MMP-3 in breast cancer tissues were positively correlated (P < 0.05). Conclusions The expression of CD15 antigen, CD44v6 and MMP-3 protein in breast tumor tissue has a certain relevance. The expression of CD15 antigen, CD44v6 and MMP-3 protein has important reference value to degree of invasion and malignant lesions in the differential diagnosis of breast tumor.
作者
戚利坤
刘长春
王巍
Li-kun Qi;Chang-chun Liu;Wei Wang(Department of Surgical Oncology, Qinghai Province Cancer Hospital, Qinghai, Xining 810007, China)
出处
《中国现代医学杂志》
CAS
2019年第10期33-37,共5页
China Journal of Modern Medicine
