摘要
目的:探讨左甲状腺素钠联合阿仑膦酸钠对甲状腺功能减退患者心肌酶谱(AST、CK、LDH)、骨代谢指标(ⅠCTP、BGP、ALP)、对氧磷酶1(PON1)含量的影响。方法:选取2016年1月-2017年1月本院收治的80例甲状腺功能减退患者的临床资料进行回顾性分析。依据不同治疗方式将其分为对照组和试验组,各40例。对照组给予左甲状腺素钠治疗,试验组予以左甲状腺素钠联合阿仑膦酸钠治疗。比较两组治疗前后的心肌酶谱、骨代谢指标、PON1含量。结果:治疗后,试验组AST、CK、LDH水平均低于对照组,ⅠCTP、BGP、ALP、PON1水平均高于对照组,差异均有统计学意义(P<0.05)。结论:左甲状腺素钠联合阿仑膦酸钠治疗甲状腺功能减退可有效改善患者心肌酶谱、骨代谢指标水平,提升PON1含量,值得选用。
Objective:To investigate the effects of Levothyroxine Sodium combined with Alendronate Sodium on myocardial enzymes(AST,CK,LDH),bone metabolism indexes(ⅠCTP,BGP,ALP)and paraoxonase 1(PON1)in patients with hypothyroidism.Method:Clinical data of 80 patients with hypothyroidism admitted to our hospital from January 2016 to January 2017 were retrospectively analyzed.According to different treatment methods,they were divided into control group and experimental group,40 cases in each group.The control group was treated with Levothyroxine Sodium,while experimental group was treated with Levothyroxine Sodium and Alendronate Sodium.The myocardial zymogram,bone metabolism index and PON1 content before and after treatment between two groups were compared.Result:After treatment,the levels of AST,CK and LDH in experimental group were lower than those of control group,and the levels of ⅠCTP,BGP,ALP and PON1 in experimental group were higher than those of control group,the differences were statistically significant(P<0.05).Conclusion:Levothyroxine Sodium combined with Alendronate Sodium in treatment of hypothyroidism can effectively improve the level of myocardial enzymes,bone metabolism indicators and increase the content of PON1,which is worthy of selection.
作者
万幼云
韩芳芳
WANYouyun;HAN Fangfang(Wuhan Ninth Hospital,Wuhan 430081,China)
出处
《中国医学创新》
CAS
2019年第11期22-25,共4页
Medical Innovation of China
关键词
左甲状腺素钠
阿仑膦酸钠
甲状腺功能减退
心肌酶谱
骨代谢
对氧磷酶1
Levothyroxine Sodium
Alendronate Sodium
Hypothyroidism
Myocardial enzyme spectrum
Bone metabolism
Paraoxonase 1
