摘要
目的:探讨应用CRRT(连续肾脏代替)对脓毒症急性肾损伤患者进行治疗的效果以及其对患者容量状态和NT-proBNP的影响。方法:选取本院2017年2月-2018年2月收治的脓毒症急性肾损伤患者98例,将其按照随机数字表法分为对照组和研究组各49例,对照组患者采用常规治疗,研究组患者采用CRRT治疗,观察并比较两组患者容量状态、NT-proBNP水平、体征指标、生化指标以及28 d存活率。结果:研究组患者容量明显低于对照组患者(P<0.05)。治疗前,两组患者NT-proBNP水平比较差异无统计学意义(P>0.05);治疗后,研究组患者明显低于对照组(P<0.05)。治疗前,两组患者体征指标比较差异均无统计学意义(P>0.05);治疗后,两组患者SpO_2、MAP、SBP、DBP比较,差异均无统计学意义(P>0.05),研究组患者尿量明显多于对照组(P<0.05)。治疗前,两组患者生化指标比较,差异均无统计学意义(P>0.05);治疗后,研究组患者BUN、N、Scr、hs-CRP、PLT、WBC明显低于对照组(P<0.05),两组Hb水平比较差异无统计学意义(P>0.05)。研究组患者28 d存活率93.9%明显高于对照组69.4%,两组比较差异有统计学有意义(P<0.05)。结论:应用CRRT对脓毒症急性肾损伤患者进行治疗的效果更佳,能够使患者的容量状态及NT-proBNP水平得到有效改善,值得推广及应用。
Objective:To investigate the effect of CRRT(continuous kidney replacement)on the treatment of patients with acute kidney injury in sepsis and the effect on the patients’ volume state and NT-probnp. Method:98 patients with acute kidney injury in our hospital February 2017 to February 2018 were selected,in accordance with the random number table method,they were divided into control group and the treatment group, 49 cases in each group.The control group was given routine treatment,the treatment group was given CRRT. The capacity status,NT-proBNP level,signs,biochemical indicators and 28 d survival rate of two groups were observed and compared.Result:The volume of the study group was significantly lower than that of the control group(P<0.05).Before treatment,there was no significant difference in NT-proBNP level between the two groups(P>0.05);after treatment,the level of NT-proBNP in the study group was significantly lower than that in the control group(P<0.05).Before treatment,there was no significant difference in the signs between the two groups(P>0.05);after treatment,there was no significant difference in SpO2,MAP,SBP and DBP between the two groups(P>0.05),the urine volume of the study group was significantly higher than that of the control group (P<0.05).Before treatment,there was no significant difference in biochemical indexes between the two groups (P>0.05).After treatment,the levels of BUN,N,Scr,hs-CRP,PLT and WBC in the study group were significantly lower than those in the control group(P<0.05),and there was no significant difference in Hb level between the two groups(P>0.05).The 28-day survival rate of the study group was 93.9%,which was significantly higher than that of the control group 69.4%(P<0.05).Conclusion:The application of CRRT for sepsis acute kidney injury patients for better treatment,can make the patients’ volume state and NT-proBNP level has been effectively improved,it is worth promoting and application.
作者
张学城
陈志朋
钟旭
陈东
ZHANG Xuecheng;CHEN Zhipeng;ZHONG Xu
出处
《中国医学创新》
CAS
2019年第13期19-23,共5页
Medical Innovation of China
基金
2016年宝安区科技创新局医疗卫生科研项目(2016CX053)
关键词
连续肾脏代替治疗
容量状态
脓毒症急性肾损伤患者
治疗效果
Continuous renal replacement therapy
Capacity status
Patients with acute renal injury due to sepsis
Treatment effect
