摘要
壳聚糖是由甲壳素通过脱乙酰作用得到的一种天然高分子多糖,具有良好的生物相容性、抗菌性、无毒和可生物降解等优点,但壳聚糖水溶性差限制了其在很多方面的应用。为克服壳聚糖在水溶性上的不足,利用壳聚糖结构中氨基和羟基上的活泼氢进行化学改性以引进羟烷基等亲水性基团成为重要手段。本文主要对壳聚糖羟烷基化改性的方法及羟烷基壳聚糖在医药、水处理和组织工程材料等领域的研究和应用现状进行介绍,并对羟烷基壳聚糖未来的发展趋势进行了展望。
Chitosan is a high-molecular polysaccharide obtained by deacetylation of chitin,which has good biocompatibility,antibacterial activity and the advantages of being non-toxic and biodegradable. However,the poor water solubility of chitosan limits its application in many aspects. In order to overcome this shortage,the chemical modification for chitosan to introduce hydrophilic groups into the amino group and hydroxyl group of chitosan have became important methods. In this paper,different chitosan hydroxyalkylation methods are discussed. Meanwhile,the applications about the hydroxyalkyl chitosan and their derivatives in medicine,water treatment and tissue engineering materials are presented,and the future development trend of hydroxyalkyl chitosan is prospected.
作者
郭伟
蔡照胜
许琦
Guo Wei;Cai Zhaosheng;Xu Qi(School of Chemistry and Chemical Engineering, Jiangsu University , Zhenjiang 212000;School of Chemistry and Chemical Engineering, Yancheng Institute of Technology , Yancheng 224000)
出处
《化学通报》
CAS
CSCD
北大核心
2019年第4期299-309,共11页
Chemistry
基金
国家自然科学基金项目(31170543)
江苏省生物质能源与材料重点实验室开放基金项目(JSBEM201607)
江苏省研究生科研与实践创新计划项目(SJCX18_0888)资助
关键词
壳聚糖
组织工程材料
水溶性
水处理
chitosan
tissue engineering materials
water-solubility
water treatment
