摘要
目的:探讨与研究(HBV)病毒cccDNA和血清巨噬细胞移动抑制因子(MIF)的表达相关性。方法:选择2015年2月到2018年7月,在我院接受治疗的78例乙型肝炎患者作为观察组,同期选择78例非肝炎感染患者作为对照组,对两组患者血清MIF、ALT、AST、TBil的表达进行检测,并进行HBV cccDNA表达分析。结果:观察组的血清ALT、TBiL、AST含量都显著高于对照组,对比差异显著(P<0.05)。观察组的血清MIF含量为(9.08±2.19)μg/L,显著高于对照组的(1.98±0.92)μg/L(t=8.272,P=0.000)。观察组的HBV cccDNA阳性率为50.0%,对照组为2.6%,观察组的HBV cccDNA阳性率显著高于对照组(P<0.05)。直线相关分析显示观察组的血清HBV cccDNA阳性率与血清ALT、TBiL、AST、MIF含量都呈现显著正相关性(P<0.05)。结论:乙肝患者体内血清MIF水平显著升高,也伴随有HBV cccDNA的阳性表达,两者存在显著的相关性。
Objective:To investigate the correlation between the expression of hepatitis B(HBV) virus cccDNA and serum acrophage mi-gration inhibitory factor(MIF) in patients with hepatitis B. Methods:From February 2015 to July 2018,144 cases of patients with hepatitis B in our hospital were selected as the hepatitis B group,and the other 144 patients of not-HBV were selected as the control group at the same time. The serum samples and samples were collected in the two groups,the expression of serum MIF,ALT,AST,TBil,and HBV cccDNA ex- pression were given analysis. Results:The serum levels of ALT,TBiL and AST in the hepatitis B group were significantly higher than those in the control group,and the difference were significant(P < 0. 05). The content of serum MIF in hepatitis B group was 9. 08 ± 2. 19 g/L,which was obviously higher than 1. 98 ± 0. 92 g/L in the control group(t = 8. 272,P = 0. 000). The positive rate of HBV cccDNA in of hepatitis B group was 50. 0%,so that was 2. 6% in the control group. The positive rate of HBV cccDNA in of hepatitis B group was higher than that of control group(P < 0. 05). The linear correlation analysis showed that the positive rate of HBV cccDNA were positively correlated with serum ALT,TBiL,AST and MIF levels(P < 0. 05). Conclusion:The level of serum MIF in patients with hepatitis B is significantly increased,and is more accompanied by positive expression of HBV cccDNA,and there are significant correlation between them. Both of them have good clinical value.
作者
张昌艳
陈智慧
梁建英
何蓉会
李双良
ZHANG Chang-yan;CHEN Zhi-hui;LIANG Jian-ying(Department of Infection, Nanchong Central Hospital (Nanchong Sichuan, 637000)China)
出处
《中西医结合肝病杂志》
CAS
2019年第2期140-142,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
