摘要
交通事故、高空坠落、重物砸伤等原因,可能导致人体脊髓损伤(spinal cord injury, SCI)。SCI中断了人体神经信号的传输信道,患者大多高位截瘫,丧失肢体功能,大小便失禁,导致终生残疾,生活异常艰难。2016年世界卫生组织统计数据显示,全世界SCI患病率为(258～785人)/百万人口,每年新发病率为(13.8～86人)/百万人口。目前全球约有SCI患者600万人,并且每年新增约60万人。脊髓损伤一直是医学界的重难点研究课题,医生和科研人员经过长期的研究与探索,目前仍未找到有效的治疗方案来修复脊髓损伤后的微环境以及促使损伤神经的再生。该方法主要针对以下两方面问题:(1)常规的检测仪器如X射线、核磁共振MRI检查、 CT等传统仪器只是影像和形态学方面的观察,不能对脊髓损伤部位的神经细胞进行定位和实时的活性分析,致使医生和科研人员对患者的病情不能精确把握,极有可能延误患者病情,甚至危及患者生命。(2) 2013年12月,西安邮电大学量子通信团队提出采用量子中继"搭桥"的方式,即利用量子纠缠传态在脊髓损伤上断点和下断点建立"连接",来实现人体神经信号中继的方法;并联合西安交通大学医学院进行大鼠和白兔的实验,取得了突破性进展。2015年1月16日,中国科学院再生医学研究团队联合中国武警脑科医院,结合间充质干细胞,使用神经细胞再生支架完成世界首例脊髓损伤"搭桥"手术,并取得了良好的治疗效果。如何保证"搭桥"是建立在活性神经细胞上,而不是已经坏死的神经细胞上?如何找到合适的"桥墩"位置,使"搭桥"的距离尽可能小以保证神经信号传输的保真度能够尽可能的高?该文提出的方法可以实现对脊髓损伤后的神经细胞进行精确定位。光谱分析越来越广泛的被应用在生物医学领域,对某些疾病的早期发现和无创或微创的高效检测起着至关重要的作用�
Traffic accidents,falling from high altitude,and bruises caused by heavy objects may cause Spinal Cord Injury (SCI).SCI interrupted the transmission channel of human nerve signal.Most patients had paraplegia,lost their physical function,and had incontinence resulting in permanent disability .According to the statistics of the World Health Organization in 2016,the prevalence of SCI in the world is (258~785) per million people,and the annual incidence rate is (13.8~86) per million people.At present,there are about 6 million patients in the world,and about 600 000 people are newly added every year.SCI has been a difficult research topic in the medical community.After long-term’s research and exploration,doctors and researchers have not found an effective treatment method to repair the micro-environment and promote the regeneration of injured nerve after SCI.The method proposed in this paper focuses on the following aspects:(1) Conventional detection instruments such as X-ray,MRI,CT and others only in imaging and morphological observations,which can not locate the nerve cells in the SCI area and can not analyze the activity in real-time.As a result,doctors and researchers can’t grasp the condition of the patient accurately and it is likely to delay the patient’s condition and even endanger the patient’s life.(2) In December 2013,the quantum communication team of Xi’an University of Posts &Telecommunications proposed the quantum relay “bridge” method,which uses quantum entanglement to establish a “connection” between the upper and the lower break point of SCI to achieve human neural signal relay.And the University together with the Xi’an Jiaotong University completed the experiments on rats and rabbits which have made breakthroughs;on January16,2015,the Chinese Academy of Sciences regenerative medicine research team and the Chinese Armed Police Brain Hospital combined with mesenchymal stem cells and used nerves.The Cell Regeneration Scaffold completed the “first bypass” surgery for the first SC
作者
聂敏
芦春雷
刘蒙
杨光
裴昌幸
NIE Min;LU Chun-lei;LIU Meng;YANG Guang;PEI Chang-xing(School of Communication and Information Engineering,Xi’an University of Posts and Telecommunications,Xi’an 710121,China;School of Electronics and Information,Northwestern Polytechnical University,Xi’an 710072,China;State Key Laboratory of Integrated Services Network,Xidian University,Xi’an 710071,China)
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2019年第5期1433-1438,共6页
Spectroscopy and Spectral Analysis
基金
国家自然科学基金项目(61172071)
陕西省国际科技合作与交流计划项目(2015KW-013)
陕西省教育厅科研计划项目(16JK1711)资助
关键词
脊髓损伤
蒙特卡洛模型
近红外光谱
细胞定位
Spinal cord injury
Monte Carlo model
Near infrared light
Cell location
