摘要
目的:探讨清热化痰祛瘀方联合西药治疗慢性阻塞性肺疾病急性加重期(COPD)患者的临床疗效及安全性。方法:选取就诊并确诊为COPD的患者104例,按随机数字表法分为对照组和观察组,每组各52例,对照组采取常规西医治疗,观察组在对照组基础上联合清热化痰祛瘀方治疗,两组均治疗1周后,观察两组临床疗效、中医症候积分改善情况及安全性,同时观察两组治疗前后第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活动比值(FEV1/FVC)肺功能指标变化。结果:与治疗前相比,两组治疗后中医症候积分均有所降低,且观察组高于对照组(P<0.05);与治疗前相比,两组治疗后FEV1、FEV1/FVC水平均升高,且观察组高于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05);而两组均未见皮疹、恶心、呕吐等不良反应。结论:采取西医联合清热化痰祛瘀方治疗方案,能改善COPD患者肺功能及临床症状,且用药安全。
Objective:To explore the clinical efficacy and safety of Qingre Huatan Quyu rescription combined with western medicine in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods:104 patients who were diagnosed and diagnosed as COPD were selected,they were randomly divided into control group and observation group according to random number table,52 cases in each group.The control group was treated with conventional western medicine.The observation group was treated with Qingre Huatan Quyu rescription on the basis of the control group.After 1 week of treatment in two groups,the clinical efficacy,improvement of TCM symptom score and safety of the two groups were observed.The changes of the first second forced expiratory volume(FEV1)and the first second forced expiratory volume occupancy ratio(FEV1/FVC)of the two groups before and after treatment were also observed.Results:Compared with before treatment,the TCM symptom scores in the two groups were reduced after treatment,and those in the observation group were higher than those in the control group(P<0.05).Compared with before treatment,the levels of FEV1 and FEV1/FVC in both groups were increased after treatment,and those in the observation group were higher than those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05),and there were no adverse reactions such as rash,nausea and vomiting in the two groups.Conclusion:Western medicine combined with Qingre Huatan Quyu rescription can improve the lung function and clinical symptoms of COPD patients,and the medication is safe.
作者
王敏
陈阁
WANG Min;CHEN Ge(Xi’an Gaoxin Hospital(Xi’an 710075))
出处
《陕西中医》
2019年第5期610-612,共3页
Shaanxi Journal of Traditional Chinese Medicine
