摘要
目的探讨干扰素治疗复发性小儿喉乳头状瘤的临床效果。方法选择2014年3月—2017年9月本院收治的小儿喉乳头状瘤患者80例,按照随机数字法分为两组,各40例。对照组实施支撑喉镜下CO_2激光治疗,观察组联合使用干扰素α-2a,治疗后随访1年,比较两组复发次数及复发时间,两组治疗后炎症相关因子,如:TNF-α、IL-1和hs-CRP水平变化,统计两组整体临床治疗效果,计算有效率。结果观察组复发次数少于对照组(P <0.05),复发时间长于对照组(P<0.05),治疗后观察组炎症相关因子中:TNF-α、IL-1和hs-CRP水平低于对照组(P <0.05),观察组有效率为70.0%,高于对照组的42.5%。结论针对复发性小儿喉乳头状瘤在实施支撑喉镜治疗同时联合使用干扰素治疗,能显著减少复发次数,避免术后复发,调节机体炎症反应,提高整体临床治疗效果。
Objective To investigate the clinical effect of interferon for recurrent papillary papilloma in children.Methods 80 cases with laryngeal papilloma admitted to our hospital from March 2014 to September 2017 were enrolled.According to the random number method,they were divided into two groups,40 cases in each group.The control group was given CO2 laser treatment under the support laryngoscope.The observation group was treated with interferonα-2a.The patients were followed up for 1 year after treatment.The number of relapses and time of recurrence were compared between the two groups.The inflammation-related factors such as TNF-αwere treated in the two groups.The levels of IL-1 and hs-CRP were changed,and the overall clinical treatment effect of the two groups was counted,and the calculation efficiency was calculated.Results The number of relapses in the observation group was lower than that in the control group(P<0.05),and the recurrence time was longer than that in the control group(P<0.05).The levels of TNF-α,IL-1 and hs-CRP in the observation group were lower than those in the control group.The control group(P<0.05),the effective rate of the observation group was 70.0%,which was significantly higher than that of the control group(42.5%).Conclusion In the treatment of recurrent pediatric laryngeal papilloma with support laryngoscopy combined with interferon therapy,it can significantly reduce the number of relapses,avoid postoperative recurrence,regulate the body's inflammatory response,and improve the overall clinical treatment effect.
作者
向磊
郑玉晗
邓绍光
XIANG Lei;ZHENG Yuhan;DENG Shaoguang(Department of ENT,The First People's Hospital of Yidu City,Yidu Hubei 433100,China)
出处
《中国继续医学教育》
2019年第13期132-134,共3页
China Continuing Medical Education
关键词
干扰素
复发性
支撑喉镜
CO2激光
小儿喉乳头状瘤
炎症反应
interferon
recurrent
support laryngoscope
CO2 laser
pediatric laryngeal papilloma
inflammation
