摘要
目的探讨多巴丝肼片和普拉克索对帕金森病伴抑郁运动功能障碍和抑郁症状的影响。方法收集2016年2月—2018年4月我院帕金森病伴抑郁的100例患者,分为研究组和对照组,两组基础治疗方案均为多巴丝肼片,研究组加用普拉克索治疗。对比两组治疗前后运动功能UPDRSⅢ量表评分;两组治疗前后抑郁症状评分;两组治疗前后认知功能评分。结果两组治疗前运动功能UPDRSⅢ量表评分差异无统计学意义(P> 0.05);两组治疗后运动功能UPDRSⅢ量表评分差异有统计学意义(P <0.05);两组治疗前抑郁症状评分差异无统计学意义(P> 0.05);两组治疗后抑郁症状评分差异有统计学意义(P<0.05);两组治疗前认知功能评分差异无统计学意义(P> 0.05);两组治疗后认知功能评分差异有统计学意义(P <0.05)。结论多巴丝肼片和普拉克索能够改善帕金森病伴抑郁患者的运动功能和抑郁症状,对提高认知功能也有积极的意义。
Objective To investigate the effects of dopazide tablets and pramipexole on motor dysfunction and depressive symptoms in Parkinson's disease with depression.Methods The patients with Parkinson's disease and depression in our hospital were divided into two groups:the study group and the control group.The basic treatment of both groups were dopazide tablets.The study group was treated with pramipexole.The UPDRSⅢscores of motor function before and after treatment,depressive symptoms before and after treatment and cognitive function scores before and after treatment were compared between the two groups.Results There was no significant difference in UPDRSⅢscore before treatment between the two groups(P>0.05);there was significant difference in UPDRSⅢscore after treatment between the two groups(P<0.05);there was no significant difference in depression score before treatment between the two groups(P>0.05);and there was a poor depression score after treatment between the two groups.The difference was statistically significant(P<0.05);there was no significant difference in cognitive function score between the two groups before treatment(P>0.05);there was significant difference in cognitive function score between the two groups after treatment(P<0.05).Conclusion Dopazide tablets and pramipexole have positive effects on motor function and depressive symptoms in patients with Parkinson's disease and depression,as well as improving cognitive function.
作者
肖骋
陈梦宇
余经盛
张金武
肖劲松
XIAO Cheng;CHEN Mengyu;YU Jingsheng;ZHANG Jinwu;XIAOJinsong(Department of Neurology,Xianning Central Hospital,First Affiliated Hospital of Hubei College of Science and Technology,Xianning Hubei 437100,China;Department of Neurology,Central South Hospital,Wuhan University,Wuhan Hubei 430071,China)
出处
《中国继续医学教育》
2019年第13期122-123,共2页
China Continuing Medical Education
关键词
多巴丝肼片
普拉克索
帕金森病
抑郁
运动功能
抑郁症状
dopazide tablets
pramipexole
Parkinson's disease
depression
motor function
depressive symptoms