摘要
目的探讨术前不同新辅助化疗方案对局部晚期宫颈癌患者治疗效果的影响。方法选取2015年7月～2017年7月我院收治的84例局部晚期宫颈癌患者作为研究对象,按照随机数字表法分为对照组和研究组,每组各42例。对照组患者在术前采用顺铂+紫杉醇(TP)方案进行新辅助化疗,研究组患者则采用顺铂+多西他赛(DP)方案进行术前新辅助化疗。比较两组患者的临床效果和不良反应情况。结果两组患者的治疗总有效率比较,差异无统计学意义(P>0.05);研究组患者的骨髓抑制、胃肠道反应、神经毒性以及变态反应等发生率均低于对照组,差异有统计学意义(P<0.05);两组患者的肝肾损伤发生率比较,差异无统计学意义(P>0.05)。结论顺铂联合紫杉醇与顺铂联合多西他赛两种术前新辅助化疗方案均能有效控制局部病灶,两者治疗效果相近,顺铂联合多西他赛方案能降低患者的不良反应发生率,安全性更好,值得临床推广应用。
Objective To investigate the effect of different preoperative neoadjuvant chemotherapy regimens on the treatment of patients with locally advanced cervical cancer.Methods A total of 84 patients with locally advanced cervical cancer admitted to our hospital from July 2015 to July 2017 were selected as the study subjects,they were divided into control group and research group according to random number table method,with 42 cases in each group.The control group received neoadjuvant chemotherapy with Cisplatin plus Paclitaxel(TP)before operation,while the study group received neoadjuvant chemotherapy with Cisplatin plus Docetaxel(DP)before operation.The clinical effects and adverse reactions of the two groups were compared.Results There was no significant difference in the total effective rate between the two groups(P>0.05).The incidence of bone marrow suppression,gastrointestinal reactions,neurotoxicity and allergic reactions in the study group were lower than those in the control group,the differences were significant(P<0.05).There was no significant difference in the incidence of liver and kidney injury between the two groups(P>0.05).Conclusion Cisplatin combined with Paclitaxel and Cisplatin combined with Docetaxel can effectively control local lesions.The therapeutic effect of both regimens is similar.Cisplatin combined with docetaxel can reduce the incidence of adverse reactions in patients with better safety,which is worthy of clinical application.
作者
冯秀英
王华伟
FENG Xiu-ying;WANG Hua-wei(Medical Examination Center,the 155^th Central Hospital of People′s Liberation Army,He′nan Province,Kaifeng 475000,China)
出处
《中国当代医药》
2019年第11期74-76,共3页
China Modern Medicine
关键词
局部晚期宫颈癌
新辅助化疗
顺铂
多西他赛
紫衫醇
临床疗效
Locally advanced cervical cancer
Neoadjuvant chemotherapy
Cisplatin
Docetaxel
Purpurol
Clinical efficacy
