摘要
目的探讨多西他赛联合顺铂化疗同步放疗对中晚期宫颈癌患者的临床治疗效果及应用价值。方法选取2015年1月至2017年6月运城市中心医院肿瘤内科收治的中晚期宫颈癌患者90例,采用随机数字表法分为观察组和对照组,每组45例。两组均给予放疗,对照组给予单纯顺铂化疗,观察组采取多西他赛联合顺铂化疗。记录并比较两组治疗效果。结果观察组治疗总有效率为46.67%,对照组为22.22%,差异有统计学意义(χ^2=5.9541,P<0.05)。观察组发生胃肠道反应6例,骨髓抑制11例,肝、肾功能异常3例,放射性肠炎7例;对照组发生胃肠道反应4例,骨髓抑制13例,肾功能异常2例,放射性肠炎6例,两组不良反应发生情况比较差异未见统计学意义(χ^2=0.4500、0.2273、0.2118、0.0899,P>0.05)。结论多西他赛联合顺铂化疗同步放疗在中晚期宫颈癌患者中可以增强治疗效果,且不增加不良反应,值得在临床推广应用。
Objective To investigate the clinical efficacy and application value of docetaxel combined with cisplatin chemotherapy and concurrent radiotherapy on advanced cervical cancer. Methods Ninety patients with advanced cervical cancer who were treated in the Department of Oncology in Yuncheng Central Hospital from January 2015 to June 2017 were selected and divided into observation group and control group by random number table method, with 45 cases in each group. All patients in the two groups were given radiotherapy. Patients in control group were given cisplatin chemotherapy, and patients in observation group were treated by docetaxel plus cisplatin chemotherapy. The therapeutic effects of the two groups were recorded and compared. Results The total effective rate was 46.67% in observation group and 22.22% in control group, and the difference between the groups was statistically significant (χ^2=5.9541, P<0.05). In observation group, there were 6 cases of gastrointestinal reactions, 11 cases of myelosuppression, 3 cases of liver and kidney dysfunction, and 7 cases of radiation enteritis. The control group had 4 cases of gastrointestinal reactions, 13 cases of bone marrow suppression, 2 cases of liver and kidney dysfunction, and 6 cases of radiation enteritis. There was no significant difference between groups in conditions of complication (χ^2=0.4500, 0.2273, 0.2118, 0.0899, P>0.05). Conclusions The application of docetaxel combined with cisplatin chemotherapy and concurrent radiotherapy can enhance the therapeutic effect on patients with advanced cervical cancer without increasing incidence of adverse reactions, and it is worthy of promotion and application in clinical.
作者
梁朝晖
Liang Zhaohui(Department of Radiotherapy, Yuncheng Central Hospital, Yuncheng 044000, China)
出处
《中国实用医刊》
2019年第5期34-36,共3页
Chinese Journal of Practical Medicine
关键词
多西他赛
顺铂
化疗
放疗
宫颈癌
Docetaxel
Cisplatin
Chemotherapy
Radiotherapy
Cervical Cancer
