摘要
目的探讨妊娠期肝内胆汁淤积症行茵栀黄、熊去氧胆酸以及腺苷蛋氨酸联合治疗的临床效果。方法选取2013～2016年中山大学附属第八医院收治的妊娠期肝内胆汁淤积症患者90例,依据随机数字表法分为对照组和观察组,各45例。对照组行腺苷蛋氨酸联合熊去氧胆酸治疗,观察组在对照组基础上加用茵栀黄联合治疗。比较两组患者治疗有效率、生化指标及妊娠结局。结果观察组治疗总有效率95.56%,高于对照组82.22%(P<0.05)。治疗前两组患者总胆汁酸、谷丙转氨酶、谷草转氨酶、总胆红素等生化指标比较差异无统计学意义(P>0.05),治疗后两组上述指标均有明显改善,且观察组优于对照组(P<0.05)。两组患者早产率、剖宫产率、胎儿窘迫发生率以及新生儿平均出生体重比较,差异无统计学意义(P>0.05)。观察组产后24 h出血量少于对照组(P<0.05)。结论妊娠期肝内胆汁淤积症行茵栀黄、熊去氧胆酸及腺苷蛋氨酸联合治疗,能够提高治疗效果,改善患者生化指标及妊娠结局,有重要的临床意义。
Objective To explore clinical efficacy of the Yinzhihuang, ursodeoxycholic acid and adenosylmethionine mattel combination therapy in the treatment of intrahepatic cholestasis of pregnancy.Methods 90 patients with intrahepatic cholestasis of pregnancy who were treated in The Eighth Affiliated Hospital of Sun Yat-sen University from 2013 to 2016 were divided into control group and observation group according to random number table,with 45 cases in each group. The control group were treated by ursodeoxycholic acid and adenosylmethionine mattel,and the observation group were treated with combination of Yinzhihuang on the basis of the control group. The treatment efficacy, biochemical indicators and pregnancy outcomes were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.56%, which was higher than that of the control group(82.22 %), and the difference between the groups was statistically significant(P<0.05). There were no significant differences in biochemical indicators such as total bile acid, alanine aminotransferase, aspartate aminotransferase, and total bilirubin before treatment(P>0.05),which were significantly improved after treatment than before treatment, the difference was statistically significant(P<0.05).There was no significant difference in the preterm delivery rate, cesarean section rate, fetal distress rate and the average birth weight of the two groups(P>0.05). The 24 h postpartum hemorrhage in the observation group was less than that in the control group, and the difference was statistically significant(P<0.05). Conclusion The combination of Yinzhihuang, ursodeoxycholic acid and adenosine methionine during intrahepatic cholestasis of pregnancy can improve the therapeutic effect, improve the biochemical indicators and pregnancy outcome of patients, and has important clinical significance.
作者
郑双云
韦瑞红
陈凤英
王冰
ZHENG Shuang-yun;WEI Rui-hong;CHEN Feng-ying;WANG Bing(Department of Obstetrics and Gynecology, The Eighth Affiliated Hospital of Sun Yat - sen University y Shenzhen Guangdong 518000, P. R. China)
出处
《中国计划生育和妇产科》
2019年第4期41-44,共4页
Chinese Journal of Family Planning & Gynecotokology
关键词
妊娠期肝内胆汁淤积症
茵栀黄
熊去氧胆酸
腺苷蛋氨酸
临床效果
intrahepatic cholestasis of pregnancy
Yinzhihuang
ursodeoxycholic acid
adenosylmethionine
clinical effect
