摘要
GATA转录因子家族是一类含锌指结构的转录调节因子,其中GATA4、GATA5、GATA6在心脏发育及功能成熟的过程中发挥关键作用。大量的研究证实,GATA转录因子家族不仅参与心脏的正常发育,其突变也与人类多种先天性心脏病(congenital heart disease,CHD)的发生相关。该文主要对GATA家族基因与心脏发育的关系、GATA家族基因突变与各类先天性心脏病的关系进行综述。
The GATA transcription factor family is a type of transcription regulatory factors containing zinc finger structure, in which GATA4, GATA5 and GATA6 play a key role in the process of heart development and functional maturity.A large number of studies have confirmed that the GATA transcription factor family is not only involved in the the heart development, but also its mutations are related to the occurrence of human congenital heart diseases(CHD). This article mainly reviews the relationship between GATA family with heart development, and the relationship between GATA family gene mutation with congenital heart diseases.
作者
陈明曦(综述)
朱华(审校)
Chen Mingxi;Zhu Hua(Department of Pediatrics, Inner Mongolia People's Hospital, Hohhot 010050, China)
出处
《国际儿科学杂志》
2019年第3期194-197,共4页
International Journal of Pediatrics
