摘要
【目的】探讨糖尿病肾病(DN)患者尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的变化及其意义。【方法】选取本院健康体检的志愿者40例为A组,本院确诊的2型糖尿病患者40例(B组)、糖尿病合并微量白蛋白尿患者40例(C组,尿白蛋白/尿肌酐30~300mg/g)、糖尿病蛋白尿患者40例(D组,尿白蛋白/尿肌酐大于300mg/g)。检测四组研究对象NGAL、血肌酐(SCr)、尿素氮(BUN)、尿微量白蛋白(Um-ALB)水平并进行比较分析。【结果】C组、D组NGAL、UmALB水平高于A组、B组,差异均具有统计学意义(P<0.05);D组NGAL、SCr、BUN、UmALB水平均显著高于A组、B组、C组,差异均具有统计学意义(P<0.05)。DN患者NGAL与SCr、BUN、UmALB均呈正相关性(P<0.05)。NGA1诊断DN的临界值为80.04ng/mL,灵敏度为85.29%、特异度为76.04%、漏诊率为14.71%、误诊率为23.96%、ROC曲线下面积AUC值为0.807。【结论】DN患者早期即出现NGAL水平升高,并且与肾功能损害程度具有一定的相关性,早期检测NGAL对于DN的鉴别诊断具有一定的价值。
[Objective] To investigate the changes and significance of serum neutrophil gelatinase-associated lipid carrier protein(NGAL)in patients with diabetic nephropathy(DN).[Methods]Fourty healthy volunteers were selected as group A,40 patients with type 2 diabetes mellitus(group B),40 patients with diabetes mellitus and microalbuminuria(group C,urinary albumin/creatinine 30-300 mg/g),40 patients with diabetic albuminuria(group D,urinary albumin/creatinine greater than 300 mg/g).NGAL,serum creatinine(SCr),urea nitrogen(BUN)and urinary microalbumin(UmAL.B)levels were measured and compared among the four groups.[Results]The levels of NGAL and UmAL.B in the group C and D were significantly higher than those in the group A and the group B(P<0.05),and the levels of NGAL,SCr,BUN and UmAl.B in the group D were significantly higher than those in the group A,group B and group C(P<0.05).NGAL waspositively correlated with SCr,BUN and UmALB in DN patients(P<0.05).The critical value of NGALin diagnosing DN was 80.04 ng/mL,the sensitivity was 85.29%,the specificity was 76.04%,the missed diagnosis rate was 14.71%,the misdiagnosis rate was 23.96%,and the AUC value under ROC curve was 0.807.[Conclusion]The level of NGALincreased in the early stage of DN patients,and it has a certain correlation with the degree of renal function damage.Early detection of NGAL has a certain value in the differential diagnosis of DN.
作者
张建林
林见敏
ZHANG Jian-lin;LIN Jian-min(Department of Clinical Laboratory,Zhongshan Hospital of Qingpu Branch,Shanghai,China 201700)
出处
《医学临床研究》
CAS
2019年第3期507-509,共3页
Journal of Clinical Research
