摘要
目的:探讨35～39岁、40～44岁及≥45岁高龄孕产妇临床结局差异。方法:收集中国医科大学附属盛京医院2017年1月1日至12月31日35岁及以上住院的高龄产妇共3 395例,对其临床病例资料进行回顾性分析,将其分成35～39岁组(组1,2 888例)、40～44岁组(组2,478例)和≥45岁组(组3,29例)3组,比较3组的临床结局。结果:40～44岁组、≥45岁组与35～39岁组相比,妊娠期高血压疾病、妊娠合并子宫肌瘤、前置胎盘、产后出血、胎儿畸形发生比例、引产及流产率均增加,差异均具有统计学意义(P<0.05)。3组的平均分娩体重及平均分娩孕周随年龄段增加呈递减趋势,差异有统计学意义(P<0.05)。≥45岁组早产发生率高于另外两组,差异有统计学意义(P<0.05)。结论:40岁以上的高龄孕产妇的临床结局更差,孕期需加强监测,以更好地保证母儿健康和安全。
Objective: To examine the difference of clinical outcomes between advanced maternal age women aged 35–39, 40–44 and 45 and older. Methods: We collected 3 395 pregnant and parturien women from January 1, 2017 to December 31, 2017 aged ≥35 in Shengjing Hospital, and the clinical data were retrospectively analyzed. We divided the cases into three groups: 35–39 years of age groups (group 1, n=2 888), 40–44 years of age groups (group 2, n=478) and the age of 45 or higher group (group 3, n=29), and compared the three groups of clinical outcomes. Results: The incidence rates of gestational hypertension disease, pregnancy with uterine fibroids, placenta previa, postpartum hemorrhage, fetal malformation, odinopoeia and abortion rate were higher in group 2 and group 3 than those in group 1. The difference between the three groups was statistically significant (P<0.05). With the increase of age, the average birth weight and the average gestational week of childbirth showed a decreasing trend, and the difference was statistically significant (P<0.05). The incidence of premature birth was higher in the group 3 than in the other two groups, and the difference was statistically significant (P<0.05).Conclusion: The clinical outcome was worse in advanced maternal age women over 40 years old. Monitoring during pregnancy should be strengthened to better ensure the health and safety of the mother and child.
作者
刘颖
魏军
LIU Ying;WEI Jun(Department of Gynecology and Obstetrics, Shengjing Hospital, Affiliated to China Medical University, Shenyang 110004, China)
出处
《临床与病理杂志》
2019年第4期764-768,共5页
Journal of Clinical and Pathological Research
基金
国家重点研发计划课题(2016YFC1000408)
辽宁省自然科学基金(2015020470)~~
关键词
高龄
妊娠
并发症
妊娠结局
advanced age
pregnancy
complication
pregnancy outcome
