摘要
目的探讨血清25-羟维生素D[25-(OH)D]维生素D水平与HSP发病的关系。方法选择2017年12月～2018年12月至我院就诊的过敏性紫癜患儿49例设为实验组,另选取40例健康儿童设为健康对照组,采用化学发光法测定两组血清25-羟维生素D水平,免疫浊度法测定补体、免疫球蛋白并进行比较,分析其相关性。结果实验组血清25-(OH)D水平为(19.061±6.572)ng/ml,低于健康对照组的(30.789±1.880)ng/ml,差异有统计学意义(t=-11.628,P<0.05);Pearson相关分析或Spearman秩相关分析示,实验组血清25-羟维生素D水平与免疫球蛋白IgA水平呈负相关(r=-0.352,P<0.05),与补体(C3、C4)、免疫球蛋白(IgG、IgM)水平间无明显相关性(r=0.199、0.248、-0.165、-0.204,均P>0.05)。结论过敏性紫癜患儿中25羟维生素D可能参与了过敏性紫癜的发病过程。
Objective To investigate the relationship between serum 25-hydroxyvitamin D [25-(OH)D] vitamin D levels and the pathogenesis of HSP. Methods A total of 49 children with Henoch-Schonlein purpura who were admitted to our hospital from December 2017 to December 2018 were selected as the experimental group, and 40 healthy children were selected as the healthy control group. The serum of the two groups was determined by chemiluminescence method.- Hydroxyvitamin D levels, immunoturbidimetric assays for complement and immunoglobulin were compared and analyzed for correlation. Results The serum 25-(OH) D level in the experimental group was (19.061±6.572) ng/ml, which was lower than that in the healthy control group (30.789±1.880) ng/ml,the difference was statistically significant (t=-11.628, P<0.05);Pearson correlation analysis or Spearman rank correlation analysis showed that serum 25-hydroxyvitamin D levels in the experimental group were negatively correlated with immunoglobulin IgA levels (r=-0.352, P<0.05), and complement (C3, C4), There was no significant correlation between immunoglobulin (IgG, IgM) levels (r=0.199, 0.248,-0.165,-0.204, both P>0.05). Conclusion 25-hydroxyvitamin D may be involved in the pathogenesis of Henoch-Schonlein purpura in children with Henoch-Schonlein purpura.
作者
谢桃李
孙礼宾
XIE Tao-li;SUN Li-bin(Department of Pediatrics,Chaohu Hospital,Anhui Medical University,Anhui 238000,Hefei,China)
出处
《医学信息》
2019年第9期116-118,共3页
Journal of Medical Information
