摘要
病原菌感染对人类健康构成了严重的威胁,一类具有三型分泌系统(Type Ⅲ secretion system,T3SS)的致病菌,可以通过T3SS将效应蛋白"注射"到宿主细胞中,去干扰宿主细胞的多种信号转导通路,从而促进病原菌的增殖和传播。T3SS效应蛋白对宿主的影响被广泛研究,并且不同病原菌采取相似或不同的策略,同一种病原菌的效应蛋白又具有协同或拮抗的功能。综述了T3SS效应蛋白参与宿主细胞凋亡和焦亡信号通路过程中所发挥的功能及分子机制的最新研究进展,并进行了归纳分析,旨在为T3SS效应蛋白的深入研究提供参考和思路,从而进一步推进病原菌致病机制的研究,为防治病原菌提供理论基础。
Pathogenic bacterial infection causes a serious threat to human health.Pathogens that harbor a Type III Secretion System(T3SS)can inject effectors into host cells through T3SS and manipulate multiple signaling pathways,thereby facilitating the proliferation and dissemination of pathogens.T3SS effectors play important roles in the signaling pathways involved in apoptosis and pyroptosis of host cells.The effects of T3SS effectors on host have been widely investigated,the effectors of different pathogens exert similarly or differently functions,and the effectors of one species exhibit synergistic or antagonistic roles.Here,we reviewed the latest researches on the function and mechanism of T3SS effectors involved in cell apoptosis and pyroptosis,and made a summary and analysis.It aims to provide references and insight for intensively researching it,thus promoting research on the mechanism of pathogenic bacteria and providing theoretical basis of prevention and treatment of pathogens.
作者
朱平
杜力杰
孟昆
薛娟
杨瑾
李姗
ZHU Ping;DU Li-jie;MENG Kun;XUE Juan;YANG Jin;LI Shan(Institute of Infection and Immunity,Taihe Hospital,Hubei University of Medicine,Shiyan 442000;College of Life Science and Technology,Huazhong Agricultural University,Wuhan 430070;Bio-Medical Center,Huazhong Agricultural University,Wuhani 430070)
出处
《生物技术通报》
CAS
CSCD
北大核心
2019年第4期178-187,共10页
Biotechnology Bulletin
基金
国家重点研发计划(2018YFA0508000)
国家自然科学基金项目(31470245)
湖北省自然科学杰青项目(2015CFA030)
湖北省教育厅创新团队项目(T201713)
湖北省科技厅青年项目(2017CFB379)
太和医院精准医学项目(2016JZ19
2016JZ22
2016JZ30)
太和医院人才启动基金(RCQD002)
生物医学研究专项(太和医院战略合作)(2662018PY028)
培育专项(优秀人才培育)(2662017PY011)
华中农业大学自主创新项目(2662018JC001)
华中农业大学人才启动项目(2017RC003)
