摘要
目的:通过回顾性研究评价可手术乳腺癌患者的术前系统性炎症指标与临床病理特征及预后的相关性.方法:收集自2012年1月至2013年12月于德州市人民医院初治、病理诊断明确为乳腺癌的患者的临床病理资料,回顾分析德州市人民医院患者术前的中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)与临床病理特征及预后之间的相关性.结果:本组患者NLR及LMR的最佳截点值分别为2.63和4.37,治疗前患者的NLR及LMR和绝经状态、雌激素受体(ER)、孕激素受体(PR)及Her-2状态等临床病理特征无相关性(P>0.05),但两者均与患者TNM分期相关(P<0.05).另外,两者均与乳腺癌患者总体预后相关,低NLR组病人预后更好,与此相反,高LMR组总体预后优于低LMR组.结论:术前NLR及LMR检测有助于判断可手术乳腺癌患者的预后,高NLR及低LMR可能是影响乳腺癌患者预后的危险因素.
Objective:To evaluate the correlation of preoperative systemic inflammatory markers with clinicopathological features and prognosis in patients with operable breast cancer by retrospective study. Methods:Patients with primary breast cancer diagnosed in Dezhou Peoples’Hospital from January 2012 to December 2013 were reviewed. The data of those patients including neutrophil-lymphocyte ratio(NLR), lymphocyte-monocyte ratio (LMR) and clinicopathological characteristics were collected,and their relationships were analyzed. Results:The optimal cut-off values of NLR and LMR in this group were 2.63 and 4.37 res pectively. T here was no cor relation between N LR and L MR with clinicopathological features s uch as menopausal status,estrogen receptor (ER),progesterone receptor (PR) and Her-2 status before treatment (P>0.05). There were significant differences of TNM stages between the high and low NLR/LMR groups, and high NLR and low LMR showed higher mortality rates with worse OS. Conclusion:Preoperative NLR and LMR can help to judge the prognosis of patients with operable breast cancer. High NLR and low LMR may be risk factors for the prognosis of breast cancer patients.
作者
陈国华
王太勇
袁淑红
赵全钢
CHEN Guo-hua;WANG Tai-yong;YUAN Shu-hong;ZHAO Quan-gang(Dezhou Peoples’Hospital,Oncology Department,Dezhou Shandong 253000,China;Dezhou Peoples’Hospital,Gynecology Department,Dezhou Shandong 253000,China;School of Information Management,Dezhou University,Dezhou Shandong 253023,China)
出处
《德州学院学报》
2019年第2期29-32,共4页
Journal of Dezhou University
基金
山东省医药卫生科技发展计划项目(2017WS820)
