摘要
水通道蛋白(aquaporins,AQPs)是细胞膜上选择性转运水分子的膜内在蛋白,广泛存在于生物体内各组织器官,其生理状态的改变与许多疾病的发生发展密切相关,特别是恶性肿瘤的生长、浸润和转移。早期准确检测肿瘤细胞AQPs分布和表达水平能为肿瘤的术前诊断及分期、术后疗效评估提供更为精准的信息。近年来,以AQPs理论为基础的多b值扩散加权成像(diffusion weighted imaging,DWI)技术已展现出巨大的发展潜力,其通过表观扩散系数(apparent diffusion coefficient,ADC)的变化来反映细胞膜AQPs的分布和功能,开辟了MR分子成像的新领域。笔者对AQPs的基本结构、生理功能、肿瘤中的表达及其意义进行简要概述,同时就AQP磁共振分子成像的基本原理以及在肿瘤中的应用进行综述。
Aquaporins(AQPs), an intrinsic protein that selectively transports water molecules on the cell membrane, is widely distributed in various tissues throughout the body. Their changes in physiological and pathological state are closely related to the occurrence and development of many diseases, especially the growth, infiltration and metastasis of malignant tumors. Early accurately detecting the distribution and expression level of AQPs in tumor cells can provide more information for preoperative diagnosis, staging and postoperative efficacy evaluation. In recent years, multi b-values diffusion weighted imaging(DWI) based on the theory of AQPs,which reflects the distribution and function of cell membrane AQPs through changes in apparent diffusion coefficient(ADC), has shown great development potential and open up a new field of magnetic resonance(MR) molecular imaging. In this article, we briefly outlined the basic structure, physiological functions, expression and significance of AQPs in tumors, and reviewed the basic principle of AQP-MR molecular imaging and its application in tumors.
作者
肖刚
胡玉川
崔光彬
XIAO Gang;HU Yuchuan;CUI Guangbin(Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province,Tangdu Hospital, the Military Medical University of PLA Airforce, Xi’an 710038, China)
出处
《磁共振成像》
CAS
2019年第4期317-320,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
第四军医大学第二附属医院科技创新发展基金(编号:2017LCYJ004)~~
关键词
水通道蛋白
扩散加权成像
表观扩散系数
磁共振成像
肿瘤
aquaporin
diffusion weighted imaging
apparent diffusion coefficient
magnetic resonance imaging
tumor
