摘要
比阿培南是新一代碳青霉烯类抗菌药物,其抗菌谱广,临床应用广泛,是治疗重症感染的杀手锏。但说明书对于具体给药方案并无明确的说明,其个体化的给药研究近年来备受关注。比阿培南给药方案可以从给药剂量、给药频次、输注时间等方面来优化,具体的方案还需根据病原菌、治疗部位、治疗人群等的不同来进行选择,群体药物代谢动力学研究(ppk)结合患者个体资料、病原菌最低抑菌浓度(MIC)及药效学资料可实现个体化给药,从而优化比阿培南的给药方案。本文就近年来比阿培南给药方案研究进展作一综述。
Biapenem is one of the new-generation carbapenems antibiotics , which has wide antibacterial spectrum and extensive clinical applications. It is an important weapon in the treatment of severe infections.The dosage regimen of biapenem is not clear enough in the instructions, and research on its individualized drug administration has attracted much attention nowadays.Its dosage regimen can be optimized from many respects such as drug dosage, dosing frequency and the infusion time. Selection of the specific regimen should take the pathogen species,infection site and infection population into considuration. Individualized drug administration of biapenem can be realized based on population pharmacokinetics research in combination with the individual physiological data of patients, minimum inhibitory concentration of pathogen and clinical pharmacodynamics parameters, so as to optimize the dosage regimen of biapenem. The progress of research on dosage regimen of biapenem was introduced in this review.
作者
陈一平
马海英
CHEN Yi-ping;MA Hai-ying(The Fourth Affiliated Hospital of China Medical University ,Shenyang , Liaoning 110032 , China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2019年第7期1117-1120,共4页
Chinese Journal of Nosocomiology
关键词
比阿培南
群体药代动力学
个体化给药
Biapenem
Population pharmacokinetics
Individualized drug administration
