摘要
目的探讨在妊娠糖尿病患者(GDM)中血清胆红素水平与胰岛β细胞功能的关系。方法选取240例GDM患者,另选取220例同期行产前检查的正常糖耐量孕妇为对照组,收集血样本用于测定血脂、血糖、胰岛素及血清胆红素水平等,计算评价胰岛β细胞功能的胰岛素分泌指数(HOMA-β)。结果与对照组相比,GDM组血清胆红素水平和HOMA-β均显著降低(P<0.05);Pearson相关分析提示,在GDM患者中,HOMA-β与血清胆红素水平呈正相关(P<0.05);多元逐步回归分析提示,TC(β=-0.174,P<0.05)、TG(β=-0.190,P<0.01)、FBG(β=-0.208,P<0.001)、FINS(β=0.211,P<0.001)和血清胆红素水平(β=0.194,P<0.01)是HOMA-β的独立影响因素。结论在GDM患者中,血清胆红素水平与胰岛β细胞功能(HOMA-β)密切相关,从而为预防和治疗GDM提供新的思路。
Objective To explore the relationship between serum total bilirubin level and islet β cell function in patients with gestational diabetes mellitus(GDM).Methods A total of 240 patients with GDM were enrolletl in our study and 220 pregnant women with normal glucose tolerance were enrolled in lhe control group.Their clinical,lipid profile glucose,insulin and serum total bilirubin levels were measured.Islet β cell function was measured by HOMA-β.Results Compared with control group,patients with GDM had lower serum total bilirubin level and HOMA-β(P<0.05).Pearson correlation analysis suggests that HOMA-β is positively correlated with serum bilirubin levels in GDM patients(P<0.05).The multiple regression model analysis showed that TC(β=0.174,P<0.05),TG(β=0.190,Pv0.01),FBG(β=0.208,P<0.001),FINS(β= 0.211 ,P<0.001)and serum total bilirubin level(β= 0.194,P<0.01)were independt factors for HOMA-β.Conclusion In GDM ,senim total bilirubin level is significantly correlated with HOMA-β which can provide a new treatment strategy for the prevention and therapy of GDM.
作者
俞丁丁
张艳
费冬
王小艳
陈丹芬
YU Ding-ding;ZHANG Yan;FEI Dong;WANG Xiao-yan;CHEN Dan-fen(Obstetrics Department,the First People's Hospital of Yuhang District,Hangzhou,Zhejiang 311100,China)
出处
《中国卫生检验杂志》
CAS
2019年第7期832-834,共3页
Chinese Journal of Health Laboratory Technology
关键词
血清胆红素水平
胰岛Β细胞功能
妊娠糖尿病
Serum total bilirubin
Islet β cell function
Gestational diabetes mellitus
