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PD-1信号在肾脏疾病中的作用 被引量:1

The role of PD-1 signal in kidney disease
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摘要 程序性死亡受体1(PD-1)与其配体即程序性死亡受体-配体1(PD-L1)和程序性死亡受体-配体2(PD-L2)结合,抑制T细胞活化、增殖、分化以及细胞因子的分泌,负性调节免疫反应,参与中枢与外周免疫耐受。PD-1信号通路的紊乱与自身免疫相关性肾脏疾病、肾脏肿瘤和肾移植等密切相关,本文就PD-1信号在肾脏疾病中的作用作一综述。
出处 《国际泌尿系统杂志》 2019年第2期366-370,共5页 International Journal of Urology and Nephrology
基金 国家自然科学基金(81370787) 江苏省临床医学科技专项(SBL2014030237)。
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