摘要
目的总结玻璃体腔注射雷珠单抗(intravitreal ranibizumab injection, IVR)联合激光光凝治疗对视网膜静脉阻塞(retinal vein occlusion, RVO)继发黄斑水肿患者血管内皮生长因子(vascular endothelial growth factor, VEGF)、最佳矫正视力(best-corrected visual acuity, BCVA)、黄斑中心凹视网膜厚度(central retinal thickness, CRT)、眼压的影响。方法回顾性分析我院行IVR联合激光光凝治疗(联合组)和仅行激光光凝治疗(常规组)的RVO继发黄斑水肿患者各68例(眼)的临床资料。比较两组治疗前及治疗2周、4周时血清VEGF、BCVA、CRT、眼压水平差异。结果治疗后,两组血清VEGF及BCVA、CRT水平均较治疗前降低(P<0.01),且治疗4周时血清VEGF及BCVA、CRT水平低于治疗2周时(P<0.01);而联合组治疗后各时间点VEGF、BCVA、CRT降低程度均大于常规组(P<0.01)。两组组间与组内各时间点眼压水平比较差异均无统计学意义(P>0.05)。结论 IVR联合激光光凝治疗RVO继发黄斑水肿患者效果显著,可降低患者VEGF水平,改善视功能,且对眼压影响较小,短期并发症亦较少,临床使用价值较高。
Objective To summarize the effects of intravitreal ranibizumab injection (IVR) combined with laser photocoagulation on vascular endothelial growth factor (VEGF), the best corrected visual acuity (BCVA), central retinal thickness (CRT), and intraocular pressure in patients with macular edema (ME) secondary to retinal vein occlusion (RVO). Methods The clinical data of macular edema secondary to RVO who were treated with IVR combined with laser photocoagulation (combination group, n =68) or merely laser photocoagulation (conventional group, n =68) was retrospectively analyzed. The levels of of serum VEGF, BCVA , CRT and intraocular pressure before treatment and at 2 w and 4 w of treatment were compared between the two groups. Results After treatment, levels of serum VEGF, BCVA and CRT in the two groups were decreased compared with those before treatment ( P <0.01), and levels of serum VEGF, BCVA and CRT at 4 w of treatment were lower than those at 2 w of treatment ( P < 0.01). However, the above indexes at each time point after treatment in combination group were much lower than those in conventional group ( P <0.01). Between-group comparison and intragroup comparison showed that there were no significant differences in intraocular pressure at each time point ( P > 0.05). Conclusion IVR combined with laser photocoagulation has a significant therapeutic effect on patients with macular edema secondary to RVO, which can reduce VEGF level and improve visual function. In addition, it has less impact on intraocular pressure, fewer short-term complications and higher application value in clinical practice .
作者
岳建中
夏智渝
张安民
杨英
YUE Jian-zhong;XIA Zhi-yu;ZHANG An-min;YANG Ying(Department of Ophthalmology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China;Department of Ophthalmology, Hanjiang Hospital Affiliated to Xi'an Medical University, Hanzhong, Shaanxi 723003, China)
出处
《临床误诊误治》
2019年第4期38-43,共6页
Clinical Misdiagnosis & Mistherapy
基金
陕西省自然科学发展项目(XZ-4213H)
