摘要
目的:分析妊娠哺乳期乳腺癌患者的预后情况及其影响因素。方法:将2010年1月至2012年12月期间贵州省贵阳市妇幼保健院、贵州省医科大学和贵州省肿瘤医院收治的妊娠哺乳期乳腺癌患者60例作为研究组,选择同期收治的非妊娠哺乳期乳腺癌患者60例作为对照组,比较两组5年生存率和临床病理特征,并应用单因素和多因素Logistic回归分析患者预后的影响因素。结果:研究组5年生存率为61.67%(37/60),5年无病生存率为46.67%(28/60),均低于对照组的81.67%(49/60),73.33%(44/60)(P<0.05)。研究组肿瘤最大直径、腋淋巴结转移率、TNM分期为III期的比例、雌激素受体阳性率、Ki67细胞阳性率≥20%的比例均高于对照组(P<0.05),两组孕激素受体阳性率比较无统计学差异(P>0.05)。单因素分析显示妊娠哺乳期乳腺癌患者总生存期与肿瘤最大直径、TNM分期、Ki67细胞阳性率≥20%的比例、腋淋巴结转移率有关(P<0.05)。多因素Logistic回归分析显示,TNM分期为III期、Ki67细胞阳性率≥20%、腋淋巴结转移是影响妊娠哺乳期乳腺癌患者预后的独立危险因素(P<0.05)。结论:妊娠哺乳期乳腺癌患者的预后较差,TNM分期为III期、Ki67细胞阳性率≥20%、腋淋巴结转移是影响患者预后的危险因素,对于临床防治具有重要的启示作用。
Objective: To analyze the prognosis of breast cancer patients during pregnancy and lactation and its influencing factors. Methods: 60 cases of breast cancer in pregnant lactation period of Guiyang Maternal and Child Health-Care Hospital of Guizhou, Guizhou Medical University and Guizhou Cancer Hospital from January 2010 to December 2012 were selected as the study group. 60 cases of breast cancer without pregnancy and lactation were selected as control group. The 5 year survival rate and the clinicopathological features of the two groups were compared, and the single factor and multiple factor Logistic regression were used to analyzed the factors affecting the prognosis of patients. Results: The 5 year survival rate of the study group was 61.67%(37/60), and the 5 year disease-free survival rate was 46.67%(28/60), which were significantly lower than 81.67%(49/60), 73.33%(44/60) of the control group (P<0.05). The maximum diameter of the tumor, the rate of axillary lymph node metastasis, the ratio of TNM stage to III stage, the positive rate of estrogen receptor and the positive rate of Ki67 cells in the study group were higher than those of the control group (P<0.05). There was no significant difference in the positive rate of progesterone receptor between the two groups(P>0.05). Single factor analysis showed that the total survival time of breast cancer patients in pregnancy lactation period was related to the maximum diameter of the tumor, TNM staging, the ratio of Ki67 cell positive rate more than 20%, and the axillary lymph node metastasis rate (P<0.05). Multiple factor Logistic regression analysis showed that TNM staging was III stage, Ki67 cell positive rate was more than 20%, axillary lymph node metastasis was an independent risk factor affecting the prognosis of breast cancer patients in pregnancy (P<0.05). Conclusion: The prognosis of breast cancer patients in pregnancy lactation period was poor, TNM stage is III stage, Ki67 cell positive rate is more than 20%, axillary lymph node metastasis is a risk facto
作者
邹佳黎
周恬
何楠
吴培新
刘蜀
ZOUJia-li;ZHOU Tian;HE Nan;WUPei-xin;LIU Shu(Department of Breast,Guiyang Maternal and Child Health-Care Hospital of Guizhou Province,Guiyang,Guizhou,550001,China;Department of Breast,The Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou,550004,China;Department of Breast,Guizhou Cancer Hospital,Guiyang,Guizhou,550000,China)
出处
《现代生物医学进展》
CAS
2019年第4期759-762,共4页
Progress in Modern Biomedicine
基金
贵州省科技计划项目(黔科合LH[2015]7037号)
关键词
乳腺癌
妊娠哺乳期
生存率
预后
影响因素
Breast cancer
Pregnancy and lactation
Survival rate
Prognosis
Influencing factors
