摘要
目的探讨银杏达莫注射液联合利伐沙班治疗下肢静脉血栓的临床疗效。方法选取2014年10月—2018年1月天津市第五中心医院收治的下肢静脉血栓患者88例,随机分为对照组(44例)和治疗组(44例)。对照组患者口服利伐沙班片,10 mg/次,1次/d。治疗组在对照组基础上静脉滴注银杏达莫注射液,10～25 mL加入5%～10%的葡萄糖注射液500 mL,2次/d。两组患者均连续治疗2周。观察两组患者临床疗效,同时比较治疗前后两组患者细胞炎性因子和血液流变学指标水平。结果治疗后,对照组的总有效率为79.55%,显著低于治疗组的95.45%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)及血液流变学指标水平均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组患者上述指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论银杏达莫注射液联合利伐沙班治疗下肢静脉血栓效果良好且安全性较高,可有效降低患者细胞炎性因子和血液流变学指标水平。
Objective To investigate the clinical effect of Ginkgo Leaf Extract and Dipyridamole Injection combined with rivaroxaban in treatment of lower extremity venous thrombosis. Methods Patients(88 cases) with lower extremity venous thrombosis in the Fifth Central Hospital of Tianjin from October 2014 to January 2018 were randomly divided into control(44 cases)and treatment(44 cases) groups. Patients in the control group were po administered with Rivaroxaban Tablets, 10 mg/time, once daily.Patients in the treatment group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of the control group, 10 - 25 mL added into 5%- 10% glucose injection 500 mL, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the cytokines levels, hemorheological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.55%, which was significantly lower than 95.45% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the TNF-α,CRP, IL-8 and hemorheological indexes levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05), and these indexes levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Ginkgo Leaf Extract and Dipyridamole Injection combined with rivaroxaban has good efficacy and high safety in treatment of lower extremity venous thrombosis, which can effectively reduce the level of cytokines and hemorheological indexes.
作者
李维颜
张毅
谷顺通
LI Wei-yan;ZHANG Yi;GU Shun-tong(Department of Vascular Surgery, the Fifth Central Hospital ofTianjin, Tianjin 300450, China)
出处
《现代药物与临床》
CAS
2019年第3期810-814,共5页
Drugs & Clinic
