摘要
目的探讨超声检测颈动脉粥样硬化(CAS)斑块对缺血性脑血管病(ICVD)的意义。方法选取2015年9月至2016年8月收治的脑梗死患者100例为观察组,另选取同期健康体检自愿者50例为对照组,2组受试者分别抽取清晨空腹外周静脉血,采用生化分析仪测定血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、纤维蛋白原(FIB)、血尿酸(UA)、C-反应蛋白(CRP)水平;采用彩色多普勒超声诊断仪检测颈动脉血管内径(VD)、平均血流速度(MFV)、颈动脉内-中膜厚度(IMT),观察不同性质CAS斑块检出情况。结果观察组TG、TC、LDL水平显著高于对照组,HDL水平显著低于对照组,差异有统计学意义(P<0.05);观察组UA、CRP、FIB水平显著高于对照组(P<0.05);观察组ICA和CCA的VD显著小于对照组,MFV显著大于对照组,IMT显著大于对照组(P<0.05);观察组AS斑块发生率及软斑、溃疡斑发生率显著高于对照组(P<0.05)。结论颈动脉超声检查和血生化指标的测定是一种简便、经济、准确性高、重复性好的方法,能够及时了解CAS斑块、颈动脉狭窄程度,对预防及治疗ICVD具有重要临床意义。
Objective To explore the correlation between carotid atherosclerostic (CAS) plaque and ischemic cerebrovascular disease (ICVD). Methods A total of 100 patients with cerebral infarction who were admitted and treated in our hospital from September 2015 to August 2016 were enrolled as observation group,and the other 50 healthy volunteers who underwent physical examinations in our hospital were enrolled as control group. The morning fasting peripheral venous blood specimens were collected in both groups. The serum levels of TC, TG, LDL, HDL, FIB, UA, and CRP were detected by biochemistry analyzer,and the color Doppler ultrasound diagnostic apparatus was used to detect VD, MFV, and IMT, CAS plaques. Results The serum levels of TG, TC, and LDL in observation group were significantly higher than those in control group, however, the HDL levels were significantly lower than those in control group( P <0.05).Moreover the levels of UA, CRP, and FIB in observation group were significantly higher than those in control group( P <0.05).The VD of ICA and CCA in observation group were significantly less than those in control group( P <0.05), while MFV and IMT were significantly greater than those in control group( P <0.05). The incidence rates of AS plaque, soft plaque, and ulcer plaque in observation group were significantly higher than those in control group( P <0.05). Conclusion The carotid ultrasound examination and detection of blood biochemical indicators are a simple and economical method with high accuracy and good repeatability,which can timely understand CAS plaque and carotid artery stenosis degree,it is of important clinical significance in prevention and treatment of ICVD.
作者
沈文
陈兰英
张学林
杨庆华
SHEN Wen;CHEN Lanying;ZHANG Xuelin(Department of Neurology, The Second Affiliated Hospital of Hebei North University, Hebei, Zhangjiakou 075100,China)
出处
《河北医药》
CAS
2019年第7期1051-1053,1057,共4页
Hebei Medical Journal
基金
张家口市科学技术研究与发展指导计划项目(编号:1221046D)
关键词
颈动脉粥样硬化斑块
多普勒超声
缺血性脑血管病
颈动脉内-中膜厚度
血流动力学
carotid atherosclerostic plaque
color Doppler ultrasound
ischemic cerebrovascular disease
carotid intima-media thickness
hemodynamics
