摘要
目的探索室内空气质量危险因素对儿童急性上呼吸道感染的影响。方法采用了前瞻性开放式队列研究方法,在2013年开始共募集6 035名学龄儿童(8～12岁)作为基线人群,2014—2017年逐年开展随访,观察队列人群急性上呼吸道感染发病情况,分析室内空气质量相关危险因素对儿童急性上呼吸道感染发病的影响。结果队列在2014—2017年逐年开展随访,4年分别随访1 824、3 064、3 177、3 151人,经协变量校正后统计分析结果显示,房屋面积不足50m^2(RR=1.304,95%CI=1.036～1.642)、购置大家具距今不足半年(RR=1.287,95%CI=1.008～1.643)、每周3d以上二手烟暴露(RR=1.314,95%CI=1.049～1.646)、饲养宠物(RR=1.198,95%CI=1.014～1.417)、使用家用化学品(RR=1.321,95%CI=1.164～1.498)是影响儿童急性上呼吸道感染的室内空气质量危险因素。结论队列研究证实室内空气质量危险因素能够影响学龄儿童急性上呼吸道感染发病。
Objectives To evaluate the effect of indoor air pollution on the incidence of acute upper respiratory infections in schoolchildren. Methods A prospective and dynamic cohort investigation was designed in this study. A total of 6 035 schoolchildren (8-12 years old) were recruited as baseline population beginning in 2013. The follow-up was conducted year by year from 2014 to 2017 to observe the incidence of acute upper respiratory infections in the cohort. The RR (Relative risk) and 95% CI (95% confidence interval) were calculated with the multiple logistic regression model to evaluate the effect of indoor air pollution risk factors on the incidence of acute upper respiratory infections in schoolchildren. Results The cohort was followed up from 2014 to 2017. 1 824 , 3 064, 3 177 and 3 151 schoolchildren were followed up in the four years, respectively. After covariate correction, the statistical analysis results revealed that, residential housing area less than 50 m^2(RR=1.304, 95% CI=1.036~1.642), purchase of large furniture less than half a year ago (RR=1.287, 95% CI=1.008~1.643), passive smoking more than 3 days per week (RR=1.314, 95% CI=1.049~1.646), keeping pets (RR=1.198, 95% CI=1.014~1.417), and use of household chemicals (RR=1.321, 95% CI=1.164~1.498) were risk factors for acute upper respiratory infections in children. Conclusion Cohort study reveals that indoor air pollution risk factors can affect the incidence of acute upper respiratory infections in schoolchildren.
作者
侯常春
冯利红
赵岩
王玉雯
张献伟
张经纬
曾强
于浩
HOU Changchun;FENG Lihong;ZHAO Yan;WANG Yuwen;ZHANG Xianwei;ZHANG Jingwei;ZENG Qiang;YU Hao(Institute of Environment and Health,Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China;Occupational Disease Prevention and Control Office,Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China)
出处
《公共卫生与预防医学》
2019年第2期9-13,共5页
Journal of Public Health and Preventive Medicine
基金
国家自然科学基金面上项目(81872590)
天津市卫生行业重点攻关项目(16KG170)
关键词
前瞻性研究
开放队列
室内空气质量
急性上呼吸道感染
学龄儿童
Prospective study
Dynamic cohort
Schoolchildren
Indoor air pollution
Acute upper respiratory infections
