摘要
目的:对比评价细针穿刺颈部淋巴结洗脱液甲状腺球蛋白(FNA-Tg)的浓度测定与细针穿刺淋巴结活检对具有超声甲状腺乳头状癌(PTC)转移征象的淋巴结转移诊断的效能。方法:选取在医院就诊的139例PTC患者(140枚淋巴结),进行细针穿刺洗脱液甲状腺球蛋白(FNA-Tg)浓度测定及细针穿刺细胞学活检(FNAC),以术后病理作为金标准,绘制受试者工作特征曲线(ROC),寻找FNA-Tg诊断转移淋巴结的最佳诊断值,并比较FNA-Tg、FNA对淋巴结转移的诊断效能。结果:FNA-Tg诊断转移淋巴结的敏感度为95.5%,特异度为97.3%,准确度为96.4%;FNAC诊断转移淋巴结的敏感度为66.7%,特异度为100%,准确度为84.3%;FNA-Tg与FNAC的准确率比较,差异有统计学意义(x2=17.814,P<0.01)。结论:FNA-Tg检测可以作为诊断PTC颈部淋巴结是否转移的方法,该检测方法显著提高了细针穿刺活检诊断的敏感性和准确性。
Objective: To compare and evaluate the efficiencies of the titer of fine needle aspiration-thyroglobulin (FNATg) and fine needle aspiration cytodiagnosis (FNAC) in diagnosing lymphatic metastasis with metastasis sign of papillary thyroid carcinoma under ultrasound. Methods: 139 patients with PTC (140 lymph nodes) were selected to undergo detection of FNA-Tg concentration and FNAC, and the pathologic results were taken as the gold standard. And the receiver operating characteristics (ROC) curve was drawn to find the optimal diagnostic value of FNA-Tg in diagnosing metastatic lymph node. And the diagnostic efficiencies of FNA-Tg and FNAC in diagnosing lymph metastasis were compared. Results: The sensitivity, specificity and accuracy of FNA-Tg were 95.5%, 97.3% and 96.4%, respectively. And those of FNAC were 66.7%, 100% and 84.3%, respectively. The differences of accuracy between FNA-Tg and FNAC were significant (x2=17. 814, P<0.01). Conclusions: The detection of FNA-Tg can be used as method that diagnoses whether PTC metastasizes at lymph node of neck, and this method significantly enhances sensitivity and accuracy of FNAC.
作者
李维生
钱林学
刘玉江
LI Wei-sheng;QIAN Lin-xue;LIU Yu-jiang(Department of Ultrasonography,Liangxiang Hospital of Fangshan District of Beijing,Beijing 102401,China)
出处
《中国医学装备》
2019年第4期56-58,共3页
China Medical Equipment
关键词
高频超声
甲状腺乳头状癌
细针穿刺活检
淋巴结转移
甲状腺球蛋白
High-frequency ultrasound
Papillary thyroid carcinoma
Fine-needle aspiration biopsy
Lymphatic metastasis
Thyroglobulin
