摘要
目的长时程亚低温疗法对重型颅脑损伤患者术后凝血功能、氧化应激损伤和炎性因子水平的影响。方法随机将128例重型颅脑损伤患者分为2组,各64例。对照组实施常规救治,观察组在对照组基础上联合亚低温治疗。比较2组患者治疗前后GCS评分、凝血系统、氧化应激损伤及炎性因子水平和并发症发生率。结果治疗前,2组患者的GCS评分、凝血功能、氧化应激损伤及炎性因子等指标差异无统计学意义(P>0.05)。治疗后,2组患者的上述指标均有改善,但观察组改善幅度优于对照组,总有效率(71.88%)高于对照组(53.13%)。观察组迟发颅内血肿、纤溶亢进发生率低于对照组,低血压发生率高于对照组,差异均有统计学意义(P<0.05)。2组肺炎发生率无统计学意义(P>0.05)。结论长时程亚低温疗法能改善重型颅脑损伤患者凝血功能、氧化应激损伤及炎性因子水平。
Objective The influence of long term hypothermia therapy on coagulation system、oxidative stress injury、inflammatory factor level of severe brain injury patients.Methods Totally 128 cases of severe craniocerebral injury were randomly divided into two groups, 64 cases in each group. The control group was treated with routine treatment, and the observation group was treated with mild hypothermia on the basis of the control group. GCS score, coagulation system, stress oxidative damage, inflammatory factor level and incidence of complications were compared between the two groups before and after treatment.Results Before treatment, GCS、coagulation system、oxidative stress injury、inflammatory factor level of the two groups had no difference(P>0.05);after treatment, the above indexes were improved,but the improvement rate of the observation group was better than that of the control group,and total efficiency(71.86%) was higher than that of control group(53.13%);delayed traumatic hematoma、hyperfibrinolysis occurrence rate was lower than that of control group, hypotension occurrence rate was higher than that of control group, the difference was statistic ally significant(P<0.05), difference of pneumonia occurrence rate had no statistic significance(P>0.05).Conclusion Long term hypothermia therapy can avoid coagulation system、oxidative stress injury、and the inflammatory factor level.
作者
马军辉
Ma Junhui(Ruyang County People's Hospital Neurosurgery,Ruyang Henan 471200,China)
出处
《河南外科学杂志》
2019年第2期5-7,共3页
Henan Journal of Surgery
关键词
亚低温
重型颅脑损伤
凝血系统、氧化应激损伤
炎性因子水平
hypothermia therapy
severe brain injury
coagulation system
oxidative stress injury
inflammatory factor level
