摘要
目的:全自动一体化合成水甘油通道蛋白分子探针^(11)C-N-甲基-3-氨基-1,2-丙二醇,并用以大鼠肝脏PET/CT显像。方法:使用GE TRACERlab FX C Pro合成平台合成^(11)C-N-甲基-3-氨基-1,2-丙二醇后,对Wistar大鼠进行^(11)C-N-甲基-3-氨基-1,2-丙二醇动态扫描,观察肝脏放射性摄取及随时间变化情况,绘制时间-放射性活度曲线。结果 :^(11)C-N-甲基-3-氨基-1,2-丙二醇合成效率>50%,放射性化学纯度>98%,合成时间30 min左右。PET/CT肝脏显像清楚,且随时间延长放射性摄取明显减低。结论:全自动一体化合成^(11)C-N-甲基-3-氨基-1,2-丙二醇方法简单、纯度高,可用于大鼠肝脏方面临床前期研究。
Objective: To develop a fully automatic synthesis for the preparation of aquaglycerporin imaging agent11 C-Nmythyl-3-amino-1, 2-propanediol, and to study the liver uptake in rat using PET/CT. Methods:11 C-N-mythyl-3-amino-1, 2-propanediol was automatically prepared by using TRACERlab FX C Pro system of GE Healthcare and dynamic liver scans were observed on rats, which were injected by the molecular probe11 C-N-mythyl-3-amino-1, 2-propanediol. The changes of distribution of them in liver with time elapse were observed and the curve of time-activity was plotted. Results: The synthesis efficiency of the probe was over 50%, the radiochemical purity was over 98%, the time for the process was about 30 min.The scans of PET/CT showed the distribution of the probe in liver were clear and the radioactivity decreased significantly with time going. Conclusion: The automatic preparation in producing the probe of high radiochemical is simple and easy to control, and the preclinical study of rat liver may be carried out with the new probe.
作者
陈羲
杨梦忆
曹礼
辛军
CHEN Xi;YANG Meng-yi;CAO Li;XIN Jun(Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China)
出处
《中国临床医学影像杂志》
CAS
2019年第3期179-182,共4页
Journal of China Clinic Medical Imaging
基金
国家自然科学基金面上项目(81471718)
辽宁省重点研发计划攻关项目(2017225030)
沈阳市科学技术计划项目(18014423)
