摘要
血小板在血管损伤部位的活化聚集是正常凝血的关键步骤之一,但过度的血小板聚集会形成血栓,从而引发急性缺血事件。因此,治疗血栓性疾病的重要方向之一就是抗血小板聚集。对血小板聚集机制、抗血小板聚集作用机制、血小板聚集检测方法、抗血小板聚集药物、抗血栓作用新靶点等方面进行全面综述,希望能指导抗血小板聚集相关实验的深入研究。
The activation and aggregation of platelet at the site of vascular injuiy is one of the key steps of normal coagulation ,but excessive platelet aggregation can cause thrombus and lead to acute ischemic events. Therefore, one of the important directions in the treatment of thrombotic diseases is anti - platelet aggregation. In this paper, the mechanism of platelet aggregation, the mechanism of anti - platelet aggregation, the detection methods of platelet aggregation, the antiplatelet aggregation drugs, the new targets of antithrombotic effect and so on are reviewed. It is hoped that it can be used to guide the further study of antiplatelet aggregation related experiments.
作者
许丹丹
徐雅娟
解生旭
刘悦
宝艳儒
陈奇
XU Dandan;XU Yajuan;XIE Shengxu;LIU Yue;BAO Yanru;CHEN Qi(Changchun University of Chinese Medicine,Changchun 130117 , Jilin,China;Key Laboratory of Pharmacodynamics and Substance of Traditional Chinese Medicine in Jilin Province Academy ofTraditional Chinese Medicine,Changchun 130021 ,Jilin,China;Yanbian University, Yanbian 133000,Jilin,China)
出处
《中华中医药学刊》
CAS
北大核心
2019年第3期597-601,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81573590)
吉林省自然科学基金白求恩医学专项(20160101194JC)
关键词
抗血小板聚集
作用机制
检测方法
新靶点
anti-platelet aggregation
mechanism
detecting method
new target
