摘要
目的探讨结肠癌组织中骨桥蛋白(OPN)与环氧化酶-2(COX-2)表达及临床检测意义。方法选取衡水市第四人民医院病理科2016年1月~2018年2月期间存档的100例结肠癌手术标本作为研究组,另按照1:1选取同一手术患者的100例癌旁正常组织作为研究对照组。采用免疫组化法检测两组OPN、COX-2表达情况。结果研究组OPN表达阳性率84.0%明显高于对照组17.0%(χ~2=89.789,P=0.000);研究组COX-2阳性表达率78.0%明显高于对照组32.0%(χ~2=42.747,P=0.000)。OPN阳性表达与结肠癌TNM分期、分化程度、淋巴结转移有关(P <0.05);COX-2阳性表达与结肠癌TNM分期、淋巴结转移有关(P <0.05)。结肠癌组织中OPN阳性表达与COX-2阳性表达呈正相关性(r=3.821,P=0.000)。结论通过检测OPN、COX-2表达水平对指导临床诊断和治疗结肠癌具有重要意义。
Objective To investigate the expression of osteopontin (OPN) and cyclooxygenase-2 (COX-2) in colon cancer tissues and its clinical significance. Methods 100 cases of colon cancer surgical specimens filed between January 2016 and February 2018 in the Department of Pathology, Fourth People′s Hospital of Hengshui City were selected as the study group, and 100 cases of adjacent normal tissues were selected as the study control group according to 1:1. Immunohistochemistry was used to detect the expression of OPN and COX-2 in the two groups. Results The positive rate of OPN expression in the study group was 84.0% higher than that in the control group (17.0%,χ^2=89.789, P=0.000). The positive expression rate of COX-2 in the study group was 78.0%, which was significantly higher than that in the control group (32.0%,χ^2=42.747, P=0.000). The positive expression of OPN was associated with TNM stage, differentiation and lymph node metastasis of colon cancer (P < 0.05). The positive expression of COX-2 was associated with TNM stage and lymph node metastasis of colon cancer (P < 0.05). The positive expression of OPN in colon cancer tissues was positively correlated with the positive expression of COX-2 (r=3.821, P=0.000). Conclusion It is important to guide the clinical diagnosis and treatment of colon cancer by detecting the expression levels of OPN and COX-2.
作者
赵岭岭
李景光
刘艳彩
吴春平
刘学刚
商庆花
Zhao Lingling;Li Jingguang;Liu Yancai;Wu Chunping;Liu Xuegang;Shang Qinghua(Department of Pathology,Hengshui Fourth Hospital,Hengshui 053000,China;Department of General Surgery,Hengshui Fourth Hospital,Hengshui 053000,China)
出处
《中华结直肠疾病电子杂志》
2019年第2期160-164,共5页
Chinese Journal of Colorectal Diseases(Electronic Edition)
基金
衡水市科技创新计划项目(No.2017014039Z)