摘要
目的:观察辛温止痛法治疗瘀血型偏头痛的临床疗效及可能作用机制。方法:将30例瘀血型偏头痛患者随机分为治疗组和对照组各15例。对照组服用盐酸氟桂利嗪胶囊(西比灵),治疗组服用辛温止痛中药汤剂,两组疗程均为2个月。治疗后评价临床疗效,治疗前后分别对患者中医证候、疼痛频率、持续时间、疼痛程度进行评分,并检测外周血中5-HT、CGRP的含量变化。结果:治疗组有效率为93. 33%,对照组为60. 00%,治疗组优于对照组(P <0. 05)。治疗组治疗后中医症状评分明显下降(P <0. 05),对照组治疗后中医症状评分无明显变化(P> 0. 05)。治疗后两组患者的疼痛频率、持续时间、疼痛程度评分较本组治疗前明显下降(P <0. 05)。治疗后两组外周血中5-HT含量明显升高,且治疗组明显高于对照组。CGRP的含量明显下降,且治疗组均明显低于对照组(P <0. 05)。结论:辛温止痛法可有效缓解瘀血型偏头痛患者的疼痛及全身症状,其机制可能与升高5-HT、下调外周血中CGRP的含量有关。
Objective: To observe the clinical efficacy and potential mechanism of pungent-warm analgesia method in treating patients with migraine of blood stasis type. Methods: Totally 30 patients with migraine of blood stasis type were randomized into treatment group and control group with 15 cases in each group. The control group was given flunarizine and the treatment group was given pungent-warm analgesia decoction. Both groups were treated for 2 months. The clinical efficacy was evaluated after treatment,and the Chinese medicine symptoms,the headache attack frequency,headache duration and pain degree were scored before and after treatment. The content changes of 5-HT and CGRP in peripheral blood of the patients were detected. Results: The total effective rate in the treatment group was 93. 33%,and that in the control group was 60. 00%. The effective rate in the treatment group was significantly higher than that in the control group( P < 0. 05). Chinese medicine symptoms were significantly decreased compared with those before treatment in the treatment group( P < 0. 05),which did not change significantly in control group( P > 0. 05). The headache attack frequency,duration time and pain degree of the patients in two groups were significantly decreased compared with those before treatment,which in treatment group were significantly decreased compared with those of the control group( P < 0. 05). The contents of 5-HT in the patients in two groups were significantly increased compared with those before treatment,which in treatment group were significantly increased compared with those of the control group( P < 0. 05). The contents of CGRP in the patients in two groups were significantly decreased compared with those before treatment,which in treatment group were significantly decreased compared with those of the control group( P < 0. 05). Conclusion: Pungent-warm analgesia method shows a good clinical efficacy for the patients with migraine of blood stasis type,and the mechanism seems related to down-regulate the expression
作者
李慧
伍志勇
聂玲辉
吴艳华
陈宝田
LI Hui;WU Zhiyong;NIE Linghui;WU Yanhua;CHEN Baotian(Guangzhou Red Cross Hospital, Guangzhou 510220, Guangdong, China;Nanfang Hospital, Gangzhou 510515 , Guangdong,China;Guangdong Traditional Medical and Sports Injury Rehabilitation Research Institute, Guangzhou 510317 , Guangdong, China)
出处
《辽宁中医杂志》
CAS
2019年第3期570-572,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81774239)
广州市中医药和中西医结合项目(20172A011015)
关键词
辛温止痛法
瘀血型
偏头痛
5
-HT
CGRP
pungent-warm analgesia method
blood stasis type
migraine
5-HT
CGRP
