摘要
目的验证不同留尿方式下尿碘/肌酐比值在尿碘检测中的应用价值。方法以20例健康成人志愿者为观察对象,收集1 d内的随意尿样、连续5 d的24 h尿样和晨尿样,检测所有样本的尿碘和肌酐含量。对上述3种留尿方式的尿碘/肌酐比值进行变异系数研究,将1 d内随意尿和晨尿的尿碘/肌酐比值分别与24 h尿的尿碘/肌酐比值进行对比分析。结果1 d内随意尿、晨尿、24 h尿的尿碘含量变异系数范围分别为12.5%~ 57.4%、5.4%~ 26.0%、3.4%~ 16.6%,对应的尿碘含量变异系数主要分布分别在30%、12%、8%附近。1 d内随意尿的尿碘/肌酐比值变异系数在11.6%~ 36.1%,多数变异系数分布在23%左右;连续5 d晨尿和24 h尿的尿碘/肌酐比值变异系数范围分别为3.9%~ 16.8%、4.3%~ 12.7%,对应的变异系数主要分布在10%、7%附近。随意尿、晨尿、24 h尿的尿碘/肌酐比值比较差异有统计学意义(F = 4.002,P < 0.05),其中随意尿与24 h尿的尿碘/肌酐比值比较差异有统计学意义(P < 0.05),晨尿与24 h尿的尿碘/肌酐比值比较差异也有统计学意义(P < 0.05)。结论用尿碘/肌酐比值进行校正,可减少尿液浓缩和稀释对于尿碘的影响,增强了随意尿和晨尿这两种留尿方式对于尿碘检测的意义,但仍不足以替代24 h留尿方式。
Objective To verify the application value of urinary iodine creatinine ratio in urinary iodine examination under different ways of collecting urine samples. Methods Totally 20 healthy adults were recruited and the urine samples were collected as each time random urine within 1 day, the 24 hour urine and morning urine within 5 successive days, respectively. Urinary iodine concentration and creatinine concentration in all urine specimens were determined. The coefficient of variation of urine iodine creatinine concentration ratio in each group was calculated. Paired t test was used to compare the urine iodine creatinine concentration ratio of 24 hour urine with the urine iodine creatinine concentration ratio of random urine and that of morning urine, respectively. Results The coefficient of variation of urinary iodine concentration values of random urine, morning urine and 24 hour urine samples within 1 d were 12.5%- 57.4%, 5.4%- 26.0%, 3.4%- 16.6%, respectively, and the corresponding coefficient of variation of urinary iodine concentration The main distribution is around 30%, 12%, and 8%. The coefficients of variation for random urine iodine creatinine concentration ratio within one day were 11.6%- 36.1%, while most of the coefficients of variation were around 23%. In contrast, the coefficients of variation of morning urine and 24 hour urine within 5 days were 3.9%- 16.8% and 4.3%- 12.7% and most of them were at about 10% and 7%. The difference of urinary iodine/creatinine concentration ratio between random urine, morning urine and 24 h urine sample was statistically significant (F = 4.002, P < 0.05). And the urine iodine creatinine concentration ratio of random urine were significantly different compared with that of 24 hour urine (P < 0.05). On the other hand, there was also significant difference for the urine iodine creatinine concentration ratio of morning urine compared with that of 24 hour urine (P < 0.05). Conclusions After adjusted with urinary iodine creatinine concentration ratio, the effect of urine con
作者
李红海
张勇
王宁
陈健
刘潇
Li Honghai;Zhang Yong;Wang Ning;Chen Jiati;Liu Xiao(Department of Laboratory Medicine, Tangshan Worker's Hospital, Tangshan 063000, China)
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2019年第3期239-242,共4页
Chinese Journal of Endemiology
关键词
尿
碘
肌酐
留尿方式
Urine
Iodine
Creatinine
Urine sample collection
