摘要
目的研究25-羟基维生素D[25(OH)D]在婴幼儿手足口病(HFMD)中的水平及临床意义。方法回顾性分析2016年5月-2017年10月住院的214例HFMD患者(观察组)的25(OH)D及相关实验室指标的检测结果,同时检测100例健康儿童(对照组)的这些指标并进行比较。结果手足口病患儿25(OH)D水平明显低于对照组,差异有统计学意义(t=-7.763,P<0.05)。25(OH)D缺乏组的LDH、CK、CK-MB水平明显高于25(OH)D正常组和25(OH)D不足组;同时,25(OH)D缺乏组较25(OH)D正常组有更高的心肌炎和脑炎发生率,差异有统计学意义(P<0.05)。结论 25(OH)D水平检测有助于手足口病的诊断和预后分析。
Objective To investigate the concentrations and clinical significance of serum 25-hydroxyvitamin D in cases with hand,foot and mouth disease(HFMD).Methods The levels of 25-hydroxyvitamin D and related laboratory indicators in 214 HFMD children hospitalized from May 2016 to October 2017(study group)were reviewed retrospectively,and compared with 100 healthy children(control group).Results The 25-hydroxyvitamin D level in children with HFMD was significantly lower than that in the control group,with the difference statistically significcant(t=-7.763,P<0.05).The levels of LDH,CK,and CK-MB in 25-hydroxyvitamin D deficiency group were higher than that in the 25(OH)D normal group and 25(OH)D insufficiency group(P<0.05);meanwhile,25-hydroxyvitamin D deficiency group had higher incidences of myocarditis and encephalitis than the 25-hydroxyvitamin D normal group,with the differences statistically significant(P<0.05).Conclusion 25-hydroxyvitamin D concentration might be beneficial in HFMD diagnosis and prognostic analysis.
作者
夏金星
段达荣
邹金艳
XIA Jin-xing;DUAN Da-rong;ZOU Jin-yan(The First People's Hospital of Taizhou,Taizhou,Zhejiang 318020,China)
出处
《中国卫生检验杂志》
CAS
2019年第6期734-736,共3页
Chinese Journal of Health Laboratory Technology
关键词
手足口病
25-羟基维生素D
心肌炎
脑炎
Hand, foot and mouth disease
25-hydroxyvitamin D
Myocarditis
Encephalitis
