摘要
目的探讨肝硬化病因及肝硬化Child-Pugh分级对小肠细菌过度生长(small intestinal bacterial overgrowth, SIBO)的影响。方法肝硬化患者106例为肝硬化组,其中酒精性肝硬化31例,病毒性肝硬化75例;同期体检健康者51例为对照组。2组均行乳果糖-氢呼气试验检测SIBO,比较SIBO发生率。结果肝硬化组SIBO发生率(34.9%)高于对照组(3.9%)(P<0.05);肝硬化组Child-Pugh A、B、C级者SIBO发生率(8.1%、35.5%、62.9%)依次升高(P<0.05);肝硬化组Child-Pugh A级者SIBO发生率与对照组比较差异无统计学意义(P>0.05),Child-Pugh B、C级者SIBO发生率高于对照组(P<0.05);酒精性肝硬化患者SIBO发生率(38.7%)与病毒性肝硬化(33.3%)比较差异无统计学意义(P>0.05);酒精性肝硬化Child-Pugh A、B、C级者SIBO发生率(10.0%、40.0%、63.6%)与病毒性肝硬化Child-Pugh A、B、C级者(7.4%、33.3%、62.5%)分别比较差异无统计学意义(P>0.05)。结论肝硬化患者SIBO发生率明显高于正常人群,且SIBO发生率随肝硬化Child-Pugh分级增加而增高,肝硬化病因对SIBO发生率无明显影响。
Objective To investigate the influence of different causes and Child-Pugh classification of liver cirrhosis on small intestinal bacterial overgrowth (SIBO).Methods SIBO was detected by lactulose-hydrogen breath test in 106 patients with liver cirrhosis(cirrhosis group)including 31patients with alcoholic cirrhosis and 75patients with viral cirrhosis,as well as 51healthy volunteers (control group).The incidences of SIBO were compared.Results The incidence of SIBO was significantly higher in cirrhosis group(34.9%)than that in control group(3.9%)(P<0.05), and increased gradually in patients with Child-Pugh A,B and C (8.1%,35.5%,62.9%)in turns(P<0.05).There was no significant difference in the incidence of SIBO between patients with Child-Pugh A and control group(P>0.05). The incidence of SIBO was significantly higher in patients with Child-Pugh B and C than that in control group(P<0.05). There was no significant difference in the incidence of SIBO between patients with alcoholic cirrhosis(38.7%)and viral cirrhosis(33.3%)(P>0.05).There were no significant differences in the incidence of SIBO between alcoholic cirrhosis patients with Child-Pugh A,B and C(10.0%,40.0%,63.6%)and viral cirrhosis patients with Child-Pugh A,B and C (7.4%,33.3%,62.5%)(P>0.05).Conclusion The incidence of SIBO is significantly higher in patients with cirrhosis than that in the normal population,and increases with the severity of cirrhosis.Different causes have no significant influence on the incidence of SIBO in patients with cirrhosis.
作者
张梦婷
李修岭
李毅
丁松泽
翟宇淼
郜宁
王田
晁帅恒
车寒蕊
ZHANG Mengting;LI Xiuling;LI Yi;DING Songze;ZHAI Yumiao;GAO Ning;WANG Tian;CHAO Shuaiheng;CHE Hanrui(Department of Gastroenterology, Henan Provincial People’s Hospital. People's Hospital of Zhengzhou University , Zhengzhou 450003, China)
出处
《中华实用诊断与治疗杂志》
2019年第3期254-256,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
河南省医学科技攻关计划省部共建项目(201701023)
关键词
酒精性肝硬化
病毒性肝硬化
小肠细菌过度生长
alcoholic cirrhosis
viral cirrhosis
small intestinal bacterial overgrowth
