摘要
细胞自噬是细胞自我更新和维持内环境稳态的重要生理过程,在肿瘤的发生发展及治疗中均发挥“双重性”作用。自噬通过保持基因组的稳定性抑制肿瘤的发生,同时又是肿瘤细胞存活的保护性机制。自噬提高抗肿瘤治疗有效性的同时又与肿瘤耐药、放射抵抗有关。在不同情况下应用自噬调控药物有望提高肿瘤细胞的治疗敏感性。
Autophagy is a crucial physiological process for cellular self-renewing and homeostasis,which plays a dual role in both tumorigenesis and anti-tumor treatment.It plays an antineoplastic role by maintaining genomic stability,as well as a protective role in tumorgenesis and progression.Autophagy improves the effectiveness of anti-tumor therapy,meanwhile,it involves in resistance of tumor cells to chemotherapy and irradiation.Using relevant autophagy regulators in different backgrounds is expected to become a new strategy for improving sensitivity of tumor cells to anti-tumor treatment.
作者
王鑫
宋海平
王晔
孙宏权
马学真
Wang Xin;Song Haiping;Wang Ye;Sun Hongquan;Ma Xuezhen(Department of Oncology, Second Affiliated Hospital of Qingdao University, Qingdao 266042, China;Department of General Medicine, Qingdao Fuwai Cardiovascular Hospital, Qingdao 266034, China)
出处
《国际肿瘤学杂志》
CAS
2018年第12期743-746,共4页
Journal of International Oncology
基金
CSCO-豪森肿瘤研究基金(Y-HS2017-059).
关键词
自噬
肿瘤
药物疗法
放射疗法
靶向治疗
Autophagy
Neoplasms
Drug therapy
Radiotherapy
Targeted therapy
