摘要
免疫性血小板减少症(ITP)为一种获得性自身免疫性出血性疾病,该病以患者对自身抗原的免疫失耐受导致免疫介导的血小板破坏增多与生成不足为特征。近年来,研究发现调节性T细胞(Treg)、调节性B细胞(Breg)等免疫抑制性细胞亚群数量和(或)功能的异常,在ITP的发生、发展中发挥重要作用。阐明Treg、Breg与ITP发病的关系,有望为ITP的治疗提供新思路。因此,笔者拟就Treg与Breg的免疫调节机制,及其在ITP发病机制中的作用的研究进展进行综述。
Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease characterized by an immune intolerance of the patients to autologous antigens leading to increased immune-mediated platelet destruction and insufficient production. In recent years, studies have found that the number and/or function of immunosuppressive cell subsets, such as regulatory T cells (Treg) and regulatory B cells (Breg) play an important role in the development of ITP. To elucidate the relationship between Treg, Breg and ITP is expected to provide new ideas for ITP therapy. The article reviews the immune regulation mechanisms of Treg and Breg, as well as their roles in the pathogenesis of ITP.
作者
王玉凤
文瑞婷
杨志刚
Wang Yufeng;Wen Ruiting;Yang Zhigang(Guangdong Medical University, Zhanjiang 524000,Guangdong Province,China;Institution of Military Medicine ? Academy of Military Sciences, Beijing 100850,China;Department of Hematology and Rheumatology, Affiliated Zhanjiang Central People' s Hospital of Guangdong Medical University ,Zhanjiang 524045. Guangdong Province,China)
出处
《国际输血及血液学杂志》
CAS
2019年第1期41-45,共5页
International Journal of Blood Transfusion and Hematology
基金
湛江市财政资金科技专项竞争性分配项目(2016A06003)
广东省科技计划项目(2016A020215149)
