摘要
目的了解2013—2014年山东省引起流感样疾病(influenza-like illness,ILI)暴发的病毒种类及其型别,阐述感染病毒谱。方法调查36起ILI暴发疫情,用描述性流行病学方法分析其流行病学特点,并采集咽拭子标本,采用RT-PCR方法,开展流感病毒(influenza virus,Flu)等呼吸道多病原检测。结果36起ILI暴发疫情中,35起发生在冬春季;暴发分布在山东省12个地级市,德州、济宁、莱芜各5起最多,中小学暴发最多为27起。病原学检测表明,B型流感病毒(FluB)引起的暴发最多为17起(47.2%);7起Flu检测为阴性或阳性率低的暴发,均由多病原混合感染导致。36起暴发共采集标本437份,235份(53.8%)病毒阳性,其中FluB最多,142份(32.5%);多病原检测中,II型副流感病毒最多。5~14岁组病毒阳性率最高(58.31%)。结论ILI暴发多发于冬春季,以中小学生为主。病毒是主要病原之一,优势病毒为FluB;多病原同时流行,且不同年龄组优势病毒有所不同。
Objective To understand the viral spectrum of influenza-like illness (ILI),Shandong province during 2013-2014.Methods The data of 36 ILI outbreaks were collected and analyzed.Multiple respiratory pathogens were detected with RT-PCR in pharynx swab specimens.Results Totally,35 outbreaks occurred in winter and spring,and dispersed in 12 cities;27 outbreaks happened in primary and secondary schools.Many of the outbreaks,17 (47.2%),were caused by influenza virus type B (FluB),followed by FluA HI and H3,5 (13.8%) outbreaks,respectively.Mixed infection caused 7 outbreaks.Totally 437 samples were collected,with 235 (53.8%) positive specimens,in which FluB was mostly detected,142 (32.5%).Except Flu,parainfluenza virus type 2 (PIV2) was the most frequently detected,followed by coronavirus (CoV).The constituent ratio of FluB under 15 years of age was the highest,such as CoV in 25-59 years old group and FluA H1 in others groups.Conclusions ILI outbreaks occurred mostly in primary and secondary schools.Virus was the main pathogen,with the dominant strains of FluB.However,the dominant strain in different age groups was different.
作者
宋绍霞
刘倜
张圣洋
吴巨龙
孙林
李忠
王显军
Song Shaoxia;Liu Ti;Zhang Shengyang;Wu Julong;Sun Lin;Li Zhong;Wang Xianjun(Shandong Center for Disease Control and Prevention,Shandong Provincial Key Laboratory of Disease Control and Prevention,Shandong University Institute for Prevention Medicine,Jinan 250014,China;School of Public Healthy Shandong University,Jinan 250014,China)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2019年第1期34-38,共5页
Chinese Journal of Experimental and Clinical Virology
基金
山东省医药卫生科技发展计划项目(2016WS0381)
国家科技重大专项(2014ZX09509-001001006)
山东省高校中医药抗病毒协同创新中心项目(XTCX2014B01-10)。
关键词
流感样病例
流感病毒
暴发
副流感病毒
冠状病毒
Influenza-like illness
Influenza virus
Outbreak
Parainfluenza virus
Coronavirus
