摘要
目的观察碳离子放射治疗气管腺样囊性癌的近期疗效和不良反应。方法2016年3月至2017年10月共收治10例气管腺样囊性癌患者,其中3例为复发患者(2例术后、1例放疗后复发),1例为I期疾病接受气管镜下冷冻术后无明显肿瘤残留者,其余均为局部晚期患者;10例患者均采用笔形束扫描技术的碳离子放疗,1例放疗后复发患者接受了 60 GyE分20次照射;1例冷冻术后患者及1例术后复发患考接受了 66 GyE分22次照射,其余患者均接受了 69 GyE分23次照射。结果中位随访时间5.5个月(1.5-16.4个月)。根据RECIST 1. 1标准,有可见病灶的9例患者中,3例完全缓解,2例部分缓解,4例疾病稳定。冷冻术后的1例患者无复发转移迹象"除1例患者放疗后4. 5个月出现4级气管狭窄外,其余患者未见23级放疗反应:2级急性反应包括声音嘶哑和中性粒细胞下降各1例,均在治疗后缓解;2级晚期反应为1例甲状腺功能下降.结论短期随访提示,碳离子射线治疗气管腺样囊性癌安全、有效。
Objective To observe the short-term effect and toxicities after carbon ion radiotherapy (C1RT) for tracheal adenoid cystic carcinoma ( TACC). Methods From March 2016 to October 2017, a total of 10 patients with TACC were treated using CIRT. Among them, three patients had recurrent disease (two after surgery, and one after brachytherapy), one received bronchoscopic cryosurgery for stage I disease, and the other 9 had locally advanced disease (3/6 received endoscopic treatment before CIRT). All patients received CIRT using pencil-beam scanning technique. Except that the patient with recurrent disease after brachytherapy received 60 GyE/20 Fx, the patient received cryosurgery and one recurrent patient after surgery received 66 GyE/22 Fx, all other patients received 69 GyE/23 Fx. Results The median follow-up time was 5.5( 1. 5-16. 4) months. Among the 9 patients with gross tumors, 3 patients achieved complete response, 2 achieved partial response, and 4 remained stable disease per RECIST 1. 1 criteria. The postcryosurgery patient remained no evidence of disease. Except 1 patient experienced grade 4 tracheal stenosis, no other grade M 3 adverse effects were observed. Grade 2 acute toxicities included 1 hoarseness and 1 neutropenia, both relieved after CIRT. Hypothyroidism in one patient was the only observed grade 2 late toxicity. Conclusion CIRT is safe and effective in the management of TACC during a short-lime observation.
作者
陈剑
茅静芳
麻宁一
陆嘉德
蒋国梁
Chen Jian;Mao Jingfang;Ma Ningyi;Lu Jiade;Jiang Guoliang(Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201315,China;Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai201315, China;Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai 200032,China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2019年第3期168-172,共5页
Chinese Journal of Radiation Oncology
基金
上海市科学技术委员会科研项目(15411950103)
上海市浦东新区科技发展基金民生科研专项(PKJ2017-Y52)
上海申康医院发展中心市级医院新兴前沿技术联合攻关项目(SHDC12017114)
上海市科学技术委员会自然科学基金(16ZR1433600).
关键词
气管腺样囊性癌/碳离子放射疗法
近期疗效
Tracheal adenoid cystic neoplasms/carbon ion radiotherapy
Short-term effect
