摘要
造血微环境是造血干细胞(HSC )自我更新、定向分化、维持相对稳态的重要场所,能够通过多种细胞成分因子调节造血活动。HSC是血液系统中的原始多能干细胞,存在于骨髓中,具有长期自我更新的能力和分化成各类成熟血细胞的潜能,在调节和维持体内血液系统各个细胞组分的生理平衡中具有重要作用。造血微环境时刻影响着HSC的发生发展,但造血微环境与HSC之间的具体作用机制仍不明确。文章就造血微环境的主要成分、信号通路以及其异常改变对疾病的影响进行综述:
The hematopoietic microenvironment provides an important place for hematopoietic stem cell (HSC) to self-renew, directional differentiation and maintain relative homeostasis, and it can regulate hematopoietic activity through various cellular components and factors. HSC is a primitive pluripotent stem cell in the blood system featured by the potential ability to self-renew for a long time and to differentiate into various mature blood cells, which exists in the bone marrow (BM). HSC plays an important role in regulating and maintaining the physiological balance of various cellular components of the blood system in the body, to ensure the continuous regeneration of the blood system. The hematopoietic microenvironment affects the development of HSC all the time, but the related cellular molecules and signals in the microenvironment still need to be studied in depth. This paper reviews the main components of the hematopoietic microenvironment, signaling pathways and the effects of abnormal changes on the diseases.
作者
徐昊淼
张坤
陈成顺
苏鑫
许亚梅
Xu Haomiao;Zhang Kun;Chen Chengs;Su Xin;Xu Yamei(Department of Hematology and Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China)
出处
《白血病．淋巴瘤》
CAS
2018年第12期761-765,共5页
Journal of Leukemia & Lymphoma
