摘要
目的探讨经皮穴位电刺激对腹腔镜子宫肌瘤摘除术患者术后认知功能及免疫功能的影响。方法选择2015年6月至2018年3月在河南中医药大学第三附属医院择期行腹腔镜子宫肌瘤摘除术患者90例,按抽签法分为两组。观察组45例采用经皮穴位电刺激,对照组45例给予右美托咪定静脉泵注,两组均采用常规麻醉诱导和维持。记录两组麻醉诱导前(T0)、术毕(T1)、术后24h(T2)免疫功能和血清S100β蛋白水平,并统计两组术后不良反应、术后认知功能障碍(POCD)发生率。结果T1、T2点两组CD4+、CD8+、CD4/CD8+均低于T0点,S100β蛋白水平高于T0点,且T2点水平优于T1点;组间相比,观察组优于对照组,差异有统计学意义(P<0.05)。观察组术后不良反应及POCD发生率均低于对照组,差异有统计学意义(P<0.05)。结论经皮穴位电刺激可改善腹腔镜子宫肌瘤摘除术患者免疫功能,调节S100β蛋白水平,降低认知功能障碍发生率,且不良反应少,值得临床应用。
Objective To investigate the effects of percutaneous acupoint electrical stimulation on postoperative cognitive function and immune function of patients after laparoscopic myomectomy.Methods Ninety patients who were treated by laparoscopic myomectomy in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from June 2015 to March 2018 were selected.All patients were divided into two groups by lottery,with 45 cases in each group.Patients in observation group were treated by percutaneous acupoint electric stimulation,while patients in control group were treated by intravenous infusion of dexmedetomidine.Patients in the two groups were induced and maintained by routine anaesthesia.Immune function and serum S100βprotein level were recorded before anesthesia induction(T0),after operation(T1)and 24 hours after operation(T2)in the two groups.The incidences of postoperative adverse reactions and postoperative cognitive dysfunction(POCD)were compared between the two groups.Results In the two groups,CD4+,CD8+,CD4+/CD8+at T1,T2 time point were lower than those at T0 time point,while S100βprotein level was higher than that at T0 time point,and the levels of above indexes at T2 time point were better than those at T1 time point(P<0.05).CD4+,CD8+,CD4+/CD8+,S100βof observation group were better than those of control group,and the difference was statistically significant(P<0.05).The incidences of postoperative adverse reactions and POCD in observation group were lower than those in control group,and the difference was statistically significant(P<0.05).Conclusions Transcutaneous acupoint electrical stimulation can improve the immune function of patients after laparoscopic myomectomy,regulate the level of S100βprotein and reduce the incidence of cognitive impairment.It is worthy of clinical application.
作者
李思海
杨军
Li Sihai;Yang Jun(Department of Anesthesiology,the Third A/filiated Hospital of Henan University of Traditional Chinese Medicine. Zhengzhou 450000,China)
出处
《中国实用医刊》
2019年第3期61-64,共4页
Chinese Journal of Practical Medicine
关键词
腹腔镜子宫肌瘤摘除术
经皮穴位电刺激
术后认知功能
免疫功能
Laparoscopic hysteromyoma extraction
Transcutaneous electrical acupoint stimulation
Postoperative cognitive function
Immune function
