摘要
以苯乙酮和苯甲醛为起始原料,经缩合、还原两步反应合成9个查尔醇(4a～4i);以FeCl_3为催化剂,室温条件下,在二氯甲烷中实现了1,3-二甲基巴比妥酸与查尔醇4a～4i的烷基化反应,合成了9个巴比妥酸的烷基化衍生物(5a～5i),其中5b～5i为新化合物,其结构经~1H NMR,^(13)C NMR和HR-MS(ESI)表征。
Nine charols(4a^4i)were obtained by a two-step reaction of condensation and reduction,using acetophenones and benzaldehydes as starting materials.A series of derivatives(5a^5i)were synthesized by alkylation reaction of barbituric acids with charols at room temperature in CH2Cl2,using FeCl3 as the catalyst.Among them,5b^5i were new compounds.The structures were characterized by 1HNMR,13CNMR and HR-MS(ESI).
作者
夏祥宇
王治明
马永敏
XIA Xiang-yu;WANG Zhi-ming;MA Yong-min(College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311400, China)
出处
《合成化学》
CAS
北大核心
2019年第3期189-193,共5页
Chinese Journal of Synthetic Chemistry
基金
浙江省自然科学基金资助项目(LY17H300005)
